Immunosensory signaling by carotid body chemoreceptors

Simple item page
dc.contributor.authorZapata, Patricio
dc.contributor.authorLarraín, Carolina
dc.contributor.authorReyes, Pablo
dc.contributor.authorFernández, Ricardo
dc.date.accessioned2016-12-16T19:35:00Z
dc.date.available2016-12-16T19:35:00Z
dc.date.issued2011
dc.description.abstractInjections of lipopolysaccharide (LPS) have been used to produce the signs of sepsis and study their underlying mechanisms. Intravenous (IV) injections of LPS in anesthetized cats induce tachypnea, tachycardia and hypotension, but ventilatory changes are suppressed after sectioning carotid and aortic nerves. Otherwise. LPS increases the basal frequency of carotid chemosensory discharges, but reduces ventilatory and chemosensory responses to hypoxia and nicotine injections. Increases in cytokines (IL-1 beta, IL-6 and TNF-alpha) are observed in plasma and tissues after injecting LPS. In carotid bodies perfused in vitro. TNF-alpha reduces chemosensory discharges induced by hypoxia. The rat carotid body and its sensory ganglion constitutively express LPS canonical receptor. TLR4, as well as TNF-alpha and its receptors (TNF-R1 and TNF-R2). Increases of TNF-alpha and TNF-R2 expression occur after LPS administration. The activation of peripheral and central autonomic pathways induced by LPS or IL's is partly dependent on intact vagus nerves. Thus, the carotid and vagus nerves provide routes between the immune system and CNS structures involved in systemic inflammatory responses. (C) 2011 Elsevier B.V. All rights reserved.
dc.identifier.citationRespiratory Physiology & Neurobiology, 2011, vol. 178, n° 3, p. 370-374
dc.identifier.urihttp://hdl.handle.net/11447/899
dc.identifier.urihttp://dx.doi.org/10.1016/j.resp.2011.03.025
dc.language.isoen_US
dc.subjectArterial chemoreceptors
dc.subjectAutonomic sensory pathways
dc.subjectCarotid body
dc.subjectImmune receptors
dc.subjectInflammation
dc.subjectLipopolysaccharide
dc.subjectTumor necrosis factor alpha
dc.titleImmunosensory signaling by carotid body chemoreceptors
dc.typeArtículo

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Immunosensory signalling by carotid body chemoreceptors.pdf
Size:
640.87 KB
Format:
Adobe Portable Document Format
Description:
Texto completo
Download

Collections

Artículos Medicina y Ciencias de la Salud

Implementado por OpenGeek Services