Mapping the neuroanatomy of functional decline in Alzheimer's disease from basic to advanced activities of daily living

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dc.contributor.authorSlachevsky, Andrea
dc.contributor.authorForno, Gonzalo
dc.contributor.authorBarraza, Paulo
dc.contributor.authorMioshi, Eneida
dc.contributor.authorDelgado, Carolina
dc.contributor.authorLillo, Patricia
dc.contributor.authorHenríquez, Fernando
dc.contributor.authorBravo, Eduardo
dc.contributor.authorFarias, Mauricio
dc.contributor.authorMuñoz-Neira, Carlos
dc.contributor.authorIbáñez, Agustín
dc.contributor.authorParra, Mario
dc.contributor.authorHornberger, Michael
dc.date.accessioned2020-09-07T16:31:24Z
dc.date.available2020-09-07T16:31:24Z
dc.date.issued2019-06
dc.description.abstractBackground: Impairments in activities of daily living (ADL) are a criterion for Alzheimer's disease (AD) dementia. However, ADL gradually decline in AD, impacting on advanced (a-ADL, complex interpersonal or social functioning), instrumental (IADL, maintaining life in community), and finally basic functions (BADL, activities related to physiological and self-maintenance needs). Information and communication technologies (ICT) have become an increasingly important aspect of daily functioning. Yet, the links of ADL, ICT, and neuropathology of AD dementia are poorly understood. Such knowledge is critical as it can provide biomarker evidence of functional decline in AD. Methods: ADL were evaluated with the Technology-Activities of Daily Living Questionnaire (T-ADLQ) in 33 patients with AD and 30 controls. ADL were divided in BADL, IADL, and a-ADL. The three domain subscores were covaried against gray matter atrophy via voxel-based morphometry. Results: Our results showed that three domain subscores of ADL correlate with several brain structures, with a varying degree of overlap between them. BADL score correlated mostly with frontal atrophy, IADL with more widespread frontal, temporal and occipital atrophy and a-ADL with occipital and temporal atrophy. Finally, ICT subscale was associated with atrophy in the precuneus. Conclusions: The association between ADL domains and neurodegeneration in AD follows a traceable neuropathological pathway which involves different neural networks. This the first evidence of ADL phenotypes in AD characterised by specific patterns of functional decline and well-defined neuropathological changes. The identification of such phenotypes can yield functional biomarkers for dementias such as AD.es
dc.identifier.citationSlachevsky A, Forno G, Barraza P, et al. Mapping the neuroanatomy of functional decline in Alzheimer's disease from basic to advanced activities of daily living. J Neurol. 2019;266(6):1310-1322. doi:10.1007/s00415-019-09260-wes
dc.identifier.urihttp://hdl.handle.net/11447/3409
dc.language.isoenes
dc.publisherSpringer Naturees
dc.subjectActivities of daily livinges
dc.subjectFunctional impairmentes
dc.subjectTechnology–activities of daily living questionnairees
dc.subjectAlzheimer’s diseasees
dc.titleMapping the neuroanatomy of functional decline in Alzheimer's disease from basic to advanced activities of daily livinges
dc.typeArticlees

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