Risk factors associated with faecal carriage of extended-spectrum cephalosporin-resistant Escherichia coli among dogs in Southeast Brazil

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dc.contributor.authorSalgado-Caxito, Marília
dc.contributor.authorBenavides, Julio A.
dc.contributor.authorMunita, José
dc.contributor.authorRivas, Lina
dc.contributor.authorGarcía, Patricia
dc.contributor.authorListoni, Fernando J. P.
dc.contributor.authorPaes, Antonio C.
dc.contributor.authorMoreno-Switt, Andrea I.
dc.date.accessioned2022-01-11T14:48:25Z
dc.date.available2022-01-11T14:48:25Z
dc.date.issued2021
dc.description.abstractFaecal carriage of extended-spectrum cephalosporin-resistant Escherichia coli (ESC-R E. coli) in dogs has been reported worldwide and can reduce the effectiveness of treatments against bacterial infections. However, the drivers that influence faecal carriage of ESC-R E. coli in dogs are poorly understood. The aims of this study were to estimate the prevalence of ESC-R E. coli among dogs prior to their admission to a veterinary teaching hospital and to identify risk factors associated with the faecal carriage of ESC-R E. coli. Rectal swabs (n = 130) were collected from dogs and screened for ESC-R E. coli using MacConkey agar supplemented with cefotaxime (2 μg/mL). E. coli species was confirmed by MALDI-TOF and screening of extended-spectrum beta-lactamase (ESBL) genes was conducted by multiplex PCR. Questionnaires were completed by each dog's owner to test several human and dog characteristics associated with ESC-R E. coli. The prevalence of faecal carriage of ESC-R E. coli was 9.2 % and 67 % of ESC-R E. coli isolates harboured ESBL genes including CTX-M alone or in combination with TEM. All ESC-R E. coli isolates were resistant to ceftriaxone, cefpodoxime, and cefotaxime and were susceptible to cefoxitin and carbapenems. The likelihood of carrying ESC-R E. coli was 15 times higher (OR = 14.41 [95 % CI: 1.80-38.02], p < 0.01) if the dog was treated with antibiotics 3-12 months prior to sampling and 8 times higher (OR = 7.96 [95 % CI: 2.96-92.07], p < 0.01) if the dog had direct contact with livestock, but 15 times lower (OR = 0.07 [95 % CI: 0.01-0.32], p < 0.01) if the dog was dewormed during the previous year. Our findings confirm the faecal carriage of ESC-R E. coli in subclinical dogs and call for further investigation regarding the impact of deworming on antibiotic-resistant bacteria in companion animals.es
dc.description.versionVersión publicado
dc.identifier.citationSalgado-Caxito M, Benavides JA, Munita JM, Rivas L, García P, Listoni FJP, Moreno-Switt AI, Paes AC. Risk factors associated with faecal carriage of extended-spectrum cephalosporin-resistant Escherichia coli among dogs in Southeast Brazil. Prev Vet Med. 2021 May;190:105316. doi: 10.1016/j.prevetmed.2021.105316es
dc.identifier.urihttps://doi.org/10.1016/j.prevetmed.2021.105316es
dc.identifier.urihttp://hdl.handle.net/11447/5419
dc.language.isoenes
dc.subjectAnti-Bacterial Agents / pharmacologyes
dc.subjectBrazil / epidemiologyes
dc.subjectCarrier State / microbiologyes
dc.subjectCephalosporins / pharmacologyes
dc.subjectDog Diseases / drug therapyes
dc.subjectDog Diseases / epidemiologyes
dc.subjectDog Diseases / microbiologyes
dc.subjectDrug Resistance, Bacteriales
dc.subjectEscherichia coli / drug effectses
dc.subjectEscherichia coli Infections / drug therapyes
dc.subjectEscherichia coli Infections / epidemiologyes
dc.titleRisk factors associated with faecal carriage of extended-spectrum cephalosporin-resistant Escherichia coli among dogs in Southeast Braziles
dc.typeArticlees
dcterms.sourcePreventive Veterinary Medicinees

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