Variability of quantitative measurements of metastatic liver lesions: a multi‑radiation‑dose‑level and multi‑reader comparison

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dc.contributor.authorDing, Yuqin
dc.contributor.authorMarin, Daniele
dc.contributor.authorVernuccio, Federica
dc.contributor.authorGonzalez, Fernando
dc.contributor.authorWilliamson, Hannah V.
dc.contributor.authorBecker, Hans‑Christoph
dc.contributor.authorPatel, Bhavik N.
dc.contributor.authorSolomon, Justin
dc.contributor.authorRamirez‑Giraldo, Juan Carlos
dc.contributor.authorSamei, Ehsan
dc.contributor.authorNelson, Rendon C.
dc.contributor.authorMeyer, Mathias
dc.date.accessioned2021-07-06T14:43:56Z
dc.date.available2021-07-06T14:43:56Z
dc.date.issued2020
dc.description.abstractPurpose To evaluate the variability of quantitative measurements of metastatic liver lesions by using a multi-radiation-doselevel and multi-reader comparison. Methods Twenty-three study subjects (mean age, 60 years) with 39 liver lesions who underwent a single-energy dual-source contrast-enhanced staging CT between June 2015 and December 2015 were included. CT data were reconstructed with seven different radiation dose levels (ranging from 25 to 100%) on the basis of a single CT acquisition. Four radiologists independently performed manual tumor measurements and two radiologists performed semi-automated tumor measurements. Interobserver, intraobserver, and interdose sources of variability for longest diameter and volumetric measurements were estimated and compared using Wilcoxon rank-sum tests and intraclass correlation coefficients. Results Inter- and intraobserver variabilities for manual measurements of the longest diameter were higher compared to semi-automated measurements (p < 0.001 for overall). Inter- and intraobserver variabilities of volume measurements were higher compared to the longest diameter measurement (p < 0.001 for overall). Quantitative measurements were statistically different at < 50% radiation dose levels for semi-automated measurements of the longest diameter, and at 25% radiation dose level for volumetric measurements. The variability related to radiation dose was not significantly different from the inter- and intraobserver variability for the measurements of the longest diameter. Conclusion The variability related to radiation dose is comparable to the inter- and intraobserver variability for measurements of the longest diameter. Caution should be warranted in reducing radiation dose level below 50% of a conventional CT protocol due to the potentially detrimental impact on the assessment of lesion response in the liver.es
dc.format.extent11 p.es
dc.identifier.citationAbdominal Radiology (2021) 46:226–236es
dc.identifier.urihttps://doi.org/10.1007/s00261-020-02601-8es
dc.identifier.urihttp://hdl.handle.net/11447/4130
dc.language.isoenes
dc.subjectDual-source computed tomographyes
dc.subjectRadiation dosees
dc.subjectIntraobserver variabilityes
dc.subjectInterobserver variabilityes
dc.subjectLiver metastasises
dc.titleVariability of quantitative measurements of metastatic liver lesions: a multi‑radiation‑dose‑level and multi‑reader comparisones
dc.typeArticlees

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