Avances en el tratamiento de cáncer de próstata resistente a la castración: énfasis en nuevas terapias hormonales

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dc.contributor.authorBerlin, Alejandro
dc.contributor.authorFernández, Mario
dc.date.accessioned2016-05-11T12:47:27Z
dc.date.available2016-05-11T12:47:27Z
dc.date.issued2015
dc.description.abstractProstate cancer represents the second cancer-related cause of death in North American and Chilean men. The main treatment for incurable stages of disease is surgical or pharmacological castration. However, with time and despite the addition of anti-androgens, the disease progresses to a clinical state that has been commonly referred to as “hormone refractory”. In recent years, the concept of hormone refractoriness has been challenged and replaced by “castration resistance”, acknowledging that further and optimal hormonal manipulation can be attained, beyond achieving testosterone levels at castration range. The purpose of this review is to summarize the recent therapeutic breakthroughs in the management of metastatic castrate resistant prostate cancer (mCRPC), with greater emphasis in the newer hormonal therapy agents such as Abiraterone and Enzalutamide. Future combination and sequential treatment strategies are contextualized in the current era of personalized cancer medicine and genomic characterization of prostate cancer.
dc.identifier.citationBerlin, Alejandro, & Fernández, Mario I. (2015). Avances en el tratamiento de cáncer de próstata resistente a la castración: énfasis en nuevas terapias hormonales. Revista médica de Chile, 143(2), 223-236.
dc.identifier.urihttp://hdl.handle.net/11447/244
dc.identifier.urihttp://dx.doi.org/10.4067/S0034-98872015000200010
dc.language.isospa
dc.publisherSociedad Médica de Santiago
dc.subjectAbiraterone
dc.subjectEnzalutamide
dc.subjectProstatic neoplasms
dc.subjectcastration-resistant
dc.titleAvances en el tratamiento de cáncer de próstata resistente a la castración: énfasis en nuevas terapias hormonales
dc.title.alternativeAdvances in the treatment of castration-resistant prostate cancer: emphasis in new hormonal therapies
dc.typeArtículo

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