Risk factors for rapid cycling in bipolar disorder.

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dc.contributor.authorValenti, Marc
dc.contributor.authorPacchiarotti, Isabella
dc.contributor.authorUndurraga, Juan
dc.contributor.authorBonnin, Caterina del Mar
dc.contributor.authorPopovic, Dina
dc.contributor.authorGoikolea, José
dc.contributor.authorTorrent, Carla
dc.contributor.authorHidalgo-Mazzei, Diego
dc.contributor.authorColom, Francesc
dc.contributor.authorVieta, Eduard
dc.date.accessioned2016-05-23T16:42:01Z
dc.date.available2016-05-23T16:42:01Z
dc.date.issued2015
dc.description.abstractThe aim of this study was to investigate the clinical factors associated with the development of rapid cycling, as well as to elucidate the role of antidepressants. METHODS: The present study (NCT01503489) is a prospective, naturalistic cohort study conducted in a sample of 289 patients diagnosed with bipolar disorder followed and treated for up to 14 years. The patients were divided into two groups on the basis of the development of a rapid cycling course (n = 48) or no development of such a course (n = 241), and compared regarding sociodemographic, clinical, and outcome variables. RESULTS: Among the 289 patients, 48 (16.6%) developed a rapid cycling course during the follow-up. Several differences were found between the two groups, but after performing Cox regression analysis, only atypical depressive symptoms (p = 0.001), age at onset (p = 0.015), and number of suicide attempts (p = 0.030) persisted as significantly associated with the development of a rapid cycling course. CONCLUSIONS: The development of rapid cycling during the course of bipolar disorder is associated with a tendency to chronicity, with a poorer outcome, and with atypical depressive symptomatology. Our study also suggests that the development of rapid cycling is associated with a higher use of antidepressants.
dc.identifier.citationBipolar Disorders, August 2015, vol.17, n°5, p.:549-559
dc.identifier.urihttp://hdl.handle.net/11447/311
dc.identifier.urihttp://dx.doi.org/10.1111/bdi.12288
dc.language.isoen_US
dc.publisherJohn Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
dc.subjectAntidepressants
dc.subjectBipolar disorder
dc.subjectRapid cycling
dc.titleRisk factors for rapid cycling in bipolar disorder.
dc.typeArtículo

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