Bacterial adhesion to collagens: implications for biofilm formation and disease progression in the oral cavity

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dc.contributor.authorÁlvarez, Simón
dc.contributor.authorLeiva, Camila
dc.contributor.authorSchuh, Christina
dc.contributor.authorAguayo, Sebastián
dc.date.accessioned2023-01-09T19:15:01Z
dc.date.available2023-01-09T19:15:01Z
dc.date.issued2022
dc.description.abstractCollagen is the most abundant structural protein in the body and the main component of the extracellular matrix of most tissues, including dentine and periodontal tissues. Despite the well-characterized role of collagen and specifically type-I collagen, as a ligand for host cells, its role as a substrate for bacterial adhesion and biofilm formation is less explored. Therefore, the purpose of this review is to discuss recent findings regarding the adhesion of oral bacteria to collagen surfaces and its role in the progression and severity of oral and systemic diseases. Initial oral colonizers such as streptococci have evolved collagen-binding proteins (cbp) that are important for the colonization of dentine and periodontal tissues. Also, periodontal pathogens such as Porphyromonas gingivalis and Tannerella forsythia utilise cbps for tissue sensing and subsequent invasion. The implications of bacteria-collagen coupling in the context of collagen biomaterials and regenerative dentistry approaches are also addressed. Furthermore, the importance of interdisciplinary techniques such as atomic force microscopy for the nanocharacterization of bacteria-collagen interactions is also considered. Overall, understanding the process of oral bacterial adhesion onto collagen is important for developing future therapeutic approaches against oral and systemic diseases, by modulating the early stages of biofilm formation.
dc.description.versionVersión publicada
dc.identifier.citationÁlvarez S, Leiva-Sabadini C, Schuh CMAP,Aguayo S. Bacterial adhesion to collagens: implications for biofilm formation and disease progression in the oral cavity. Crit Rev Microbiol. 2022 Feb;48(1):83-95. doi:10.1080/1040841X.2021.1944054.
dc.identifier.urihttps://doi.org/10.1080/1040841X.2021.1944054
dc.identifier.urihttps://repositorio.udd.cl/handle/11447/6909
dc.language.isoen
dc.subjectBiofilms
dc.subjectAtomic force microscopy
dc.subjectBacterial adhesion
dc.subjectDental caries
dc.subjectPeriodontal disease
dc.titleBacterial adhesion to collagens: implications for biofilm formation and disease progression in the oral cavity
dc.typeArticle
dcterms.sourceCritical reviews in microbiology

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