Liver transplantation for hepatocellular carcinoma: evaluation of the alpha-fetoprotein model in a multicenter cohort from Latin America

Simple item page
dc.contributor.authorPiñero, Federico
dc.contributor.authorTisi Baña, Matías
dc.contributor.authorde Ataide, Elaine Cristina
dc.contributor.authorHoyos Duque, Sergio
dc.contributor.authorMarciano, Sebastián
dc.contributor.authorVarón, Adriana
dc.contributor.authorAnders, Margarita
dc.contributor.authorZerega, Alina
dc.contributor.authorMenéndez, Josemaría
dc.contributor.authorZapata, Rodrigo
dc.contributor.authorMuñoz, Linda
dc.contributor.authorPadilla Machaca, Martín
dc.contributor.authorSoza, Alejandro
dc.contributor.authorMcCormack, Lucas
dc.contributor.authorPoniachik, Jaime
dc.contributor.authorPodestá, Luis G
dc.contributor.authorGadano, Adrián
dc.contributor.authorBoin, Ilka S F Fatima
dc.contributor.authorDuvoux, Christophe
dc.contributor.authorSilva, Marcelo
dc.contributor.authorLatin American Liver Research, Education and Awareness Network (LALREAN)
dc.date.accessioned2022-01-05T20:22:50Z
dc.date.available2022-01-05T20:22:50Z
dc.date.issued2016
dc.description.abstractBackground & aims: The French alpha-fetoprotein (AFP) model has recently shown superior results compared to Milan criteria (MC) for prediction of hepatocellular carcinoma (HCC) recurrence after liver transplantation (LT) in European populations. The aim of this study was to explore the predictive capacity of the AFP model for HCC recurrence in a Latin-American cohort. Methods: Three hundred twenty-seven patients with HCC were included from a total of 2018 patients transplanted at 15 centres. Serum AFP and imaging data were both recorded at listing. Predictability was assessed by the Net Reclassification Improvement (NRI) method. Results: Overall, 82 and 79% of the patients were within MC and the AFP model respectively. NRI showed a superior predictability of the AFP model against MC. Patients with an AFP score >2 points had higher risk of recurrence at 5 years Hazard Ratio (HR) of 3.15 (P = 0.0001) and lower patient survival (HR = 1.51; P = 0.03). Among patients exceeding MC, a score ≤2 points identified a subgroup of patients with lower recurrence (5% vs 42%; P = 0.013) and higher survival rates (84% vs 45%; P = 0.038). In cases treated with bridging procedures, following restaging, a score >2 points identified a higher recurrence (HR 2.2, P = 0.12) and lower survival rate (HR 2.25, P = 0.03). A comparative analysis between HBV and non-HBV patients showed that the AFP model performed better in non-HBV patients.es
dc.identifier.citationPiñero F, Tisi Baña M, de Ataide EC, Hoyos Duque S, Marciano S, Varón A, Anders M, Zerega A, Menéndez J, Zapata R, Muñoz L, Padilla Machaca M, Soza A, McCormack L, Poniachik J, Podestá LG, Gadano A, Boin IS, Duvoux C, Silva M; Latin American Liver Research, Education and Awareness Network (LALREAN). Liver transplantation for hepatocellular carcinoma: evaluation of the alpha-fetoprotein model in a multicenter cohort from Latin America. Liver Int. 2016 Nov;36(11):1657-1667es
dc.identifier.urihttp://dx.doi.org/10.1111/liv.13159es
dc.identifier.urihttp://hdl.handle.net/11447/5349
dc.language.isoen_USes
dc.subjectAlpha-fetoproteines
dc.subjectCandidate selectiones
dc.subjectLiver canceres
dc.subjectPredictiones
dc.titleLiver transplantation for hepatocellular carcinoma: evaluation of the alpha-fetoprotein model in a multicenter cohort from Latin Americaes
dc.typeArticlees

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Liver transplantation for hepatocellular carcinoma evaluation of the alpha-fetoprotein model in a multicenter cohort from Latin America.pdf
Size:
505.5 KB
Format:
Adobe Portable Document Format
Description:
Texto completo
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Artículos Medicina y Ciencias de la Salud

Implementado por OpenGeek Services