A dual treatment blocks alcohol binge-drinking relapse: Microbiota as a new player

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dc.contributor.authorEzquer, Fernando
dc.contributor.authorQuintanilla, María
dc.contributor.authorMorales, Paola
dc.contributor.authorSantapau, Daniela
dc.contributor.authorMunita, José
dc.contributor.authorMoya, Francisco
dc.contributor.authorEzquer, Marcelo
dc.contributor.authorHerrera, Mario
dc.contributor.authorIsrael, Yedy
dc.date.accessioned2022-11-14T19:43:16Z
dc.date.available2022-11-14T19:43:16Z
dc.date.issued2022
dc.description.abstractRationale: Gut microbiota communicates information to the brain. Some animals are born with a gut microbiota that predisposes to high alcohol consumption, and transplantation of fecal material from alcoholics to mice increases animal preference for ethanol. Alcohol-use-disorders are chronic conditions where relapse is the hallmark. A predictive animal model of relapse is the "alcohol deprivation effect" where ethanol re-access is allowed following chronic alcohol intake and a long alcohol deprivation. The present study evaluates the effect of gut microbiota modification on relapse, as an adjunct to N-acetylcysteine + Acetylsalicylic acid administration, which inhibits the alcohol-induced hyper-glutamatergic condition. Methods: Rats bred as heavy alcohol consumers (UChB) were allowed ethanol intake for one month, were deprived of alcohol for two-weeks and subsequently offered re-access to ethanol. Prior to ethanol re-access animals received orally either (i) vehicle-control, (ii) Lactobacillus-rhamnosus-GG after antibiotic treatment (LGG); (iii) N-acetylcysteine+Acetylsalicylic acid (NAC/ASA) or (iv) both treatments: LGG+ (NAC/ASA). Results: Marked binge drinking (1.75 g ethanol/kg in 60 min) and blood alcohol levels exceeding 80 mg/dl were observed in the control group upon ethanol-re-access. Lactobacillus-GG or (NAC+ASA) treatments inhibited alcohol intake by 66-80%. The combination of both treatments virtually suppressed (inhibition of 90%) the re-access binge-like drinking, showing additive effects. Treatment with NAC+ASA increased the levels of glutamate transporters xCT and GLT-1 in nucleus accumbens, while Lactobacillus-GG administration increased those of the dopamine transporter (DAT). Conclusions: The administration of a well-accepted probiotic may be of value as an adjunct in the treatment of alcohol-use-disorders.es
dc.description.versionVersión publicadaes
dc.identifier.citationEzquer F, Quintanilla ME, Morales P, Santapau D, Munita JM, Moya-Flores F, Ezquer M, Herrera-Marschitz M, Israel Y. A dual treatment blocks alcohol binge-drinking relapse: Microbiota as a new player. Drug Alcohol Depend. 2022 Jul 1;236:109466. doi: 10.1016/j.drugalcdep.2022.109466es
dc.identifier.urihttps://doi.org/10.1016/j.drugalcdep.2022.109466es
dc.identifier.urihttp://hdl.handle.net/11447/6659
dc.language.isoenes
dc.subjectADEes
dc.subjectAlcohol relapsees
dc.subjectGut microbiotaes
dc.subjectLactobacilluses
dc.subjectTreatmentes
dc.titleA dual treatment blocks alcohol binge-drinking relapse: Microbiota as a new playeres
dc.typeArticlees
dcterms.sourceDrug and Alcohol Dependencees

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