Functional Dysconnectivity in Ventral Striatocortical Systems in 22q11.2 Deletion Syndrome

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dc.contributor.authorTepper, Ángeles
dc.contributor.authorCuiza, Analía
dc.contributor.authorAlliende, Luz
dc.contributor.authorMena, Carlos
dc.contributor.authorRamirez, Juan
dc.contributor.authorIruretagoyena, Bárbara
dc.contributor.authorOrnstein, Claudia
dc.contributor.authorFritsch, Rosemarie
dc.contributor.authorNachar, Ruben
dc.contributor.authorGonzález, Alfonso
dc.contributor.authorUndurraga, Juan
dc.contributor.authorCruz, Juan
dc.contributor.authorNachar, Ruben
dc.contributor.authorGonzález, Alfonso
dc.contributor.authorUndurraga, Juan
dc.contributor.authorCruz, Juan
dc.contributor.authorTejos, Cristian
dc.contributor.authorFornito, Alex
dc.contributor.authorRepetto, Gabriela
dc.contributor.authorCrossley, Nicolás
dc.date.accessioned2022-11-28T13:28:09Z
dc.date.available2022-11-28T13:28:09Z
dc.date.issued2022
dc.description.abstract22q11.2 deletion syndrome (22q11.2DS) is a genetic neurodevelopmental disorder that represents one of the greatest known risk factors for psychosis. Previous studies in psychotic subjects without the deletion have identified a dopaminergic dysfunction in striatal regions, and dysconnectivity of striatocortical systems, as an important mechanism in the emergence of psychosis. Here, we used resting-state functional MRI to examine striatocortical functional connectivity in 22q11.2DS patients. We used a 2 × 2 factorial design including 125 subjects (55 healthy controls, 28 22q11.2DS patients without a history of psychosis, 10 22q11.2DS patients with a history of psychosis, and 32 subjects with a history of psychosis without the deletion), allowing us to identify network effects related to the deletion and to the presence of psychosis. In line with previous results from psychotic patients without 22q11.2DS, we found that there was a dorsal to ventral gradient of hypo- to hyperstriatocortical connectivity related to psychosis across both patient groups. The 22q11.2DS was additionally associated with abnormal functional connectivity in ventral striatocortical networks, with no significant differences identified in the dorsal system. Abnormalities in the ventral striatocortical system observed in these individuals with high genetic risk to psychosis may thus reflect a marker of illness risk.es
dc.description.versionVersión publicadaes
dc.identifier.citationTepper Á, Cuiza A, Alliende LM, Mena C, Ramirez-Mahaluf JP, Iruretagoyena B, Ornstein C, Fritsch R, Nachar R, González-Valderrama A, Undurraga J, Cruz JP, Tejos C, Fornito A, Repetto G, Crossley N. Functional Dysconnectivity in Ventral Striatocortical Systems in 22q11.2 Deletion Syndrome. Schizophr Bull. 2022 Mar 1;48(2):485-494. doi: 10.1093/schbul/sbab139.es
dc.identifier.urihttps://doi.org/doi:10.1093/schbul/sbab139es
dc.identifier.urihttp://hdl.handle.net/11447/6762
dc.language.isoenes
dc.subject22q11DSes
dc.subjectDopaminergic systemses
dc.subjectFunctional connectivityes
dc.subjectGenetic risk to psychosises
dc.subjectStriatal connectivityes
dc.subjectSchizophreniaes
dc.titleFunctional Dysconnectivity in Ventral Striatocortical Systems in 22q11.2 Deletion Syndromees
dc.typeArticlees
dcterms.sourceSchizophrenia bulletines

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