Enhanced left superior parietal activation during successful speech production in patients with left dorsal striatal damage and error-prone neurotypical participants

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dc.contributor.authorGeva, Sharon
dc.contributor.authorSchneider, Letitia
dc.contributor.authorKhan, Shamima
dc.contributor.authorLorca, Diego
dc.contributor.authorGajardo-Vidal, Andrea
dc.contributor.authorPLORAS team
dc.contributor.authorGreen, David
dc.contributor.authorPrice, Cathy
dc.date.accessioned2023-03-20T18:28:36Z
dc.date.available2023-03-20T18:28:36Z
dc.date.issued2022
dc.description.abstractFunctional imaging studies of neurotypical adults report activation in the left putamen during speech production. The current study asked how stroke survivors with left putamen damage are able to produce correct spoken responses during a range of speech production tasks. Using functional magnetic resonance imaging, activation during correct speech production responses was assessed in 5 stroke patients with circumscribed left dorsal striatal lesions, 66 stroke patient controls who did not have focal left dorsal striatal lesions, and 54 neurotypical adults. As a group, patients with left dorsal striatal damage (our patients of interest) showed higher activation than neurotypical controls in the left superior parietal cortex during successful speech production. This effect was not specific to patients with left dorsal striatal lesions as we observed enhanced activation in the same region in some patient controls and also in more error-prone neurotypical participants. Our results strongly suggest that enhanced left superior parietal activation supports speech production in diverse challenging circumstances, including those caused by stroke damage. They add to a growing body of literature indicating how upregulation within undamaged parts of the neural systems already recruited by neurotypical adults contributes to recovery after stroke.
dc.description.versionVersión aceptada
dc.identifier.citationGeva S, Schneider LM, Khan S, Lorca-Puls DL, Gajardo-Vidal A; PLORAS team; Hope TMH, Green DW, Price CJ. Enhanced left superior parietal activation during successful speech production in patients with left dorsal striatal damage and error-prone neurotypical participants. Cereb Cortex. 2022 Aug 13:bhac282. doi: 10.1093/cercor/bhac282
dc.identifier.doihttps://doi.org/doi: 10.1093/cercor/bhac282
dc.identifier.urihttps://repositorio.udd.cl/handle/11447/7102
dc.language.isoen
dc.subjectAphasia
dc.subjectfMR
dc.subjectPutamen
dc.subjectRecovery
dc.subjectStroke
dc.titleEnhanced left superior parietal activation during successful speech production in patients with left dorsal striatal damage and error-prone neurotypical participants
dc.typeArticle
dcterms.accessRightsAcceso abierto
dcterms.sourceCerebral cortex

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