SFPQ associates to LSD1 and regulates the migration of newborn pyramidal neurons in the developing cerebral cortex

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dc.contributor.authorSauda, K
dc.contributor.authorCanovas, J
dc.contributor.authorLopez, CI
dc.contributor.authorBerndt, FA
dc.contributor.authorLopez, E
dc.contributor.authorMaass, JC
dc.contributor.authorBarriga, A
dc.contributor.authorKukuljana, M
dc.date.accessioned2017-10-05T15:02:44Z
dc.date.available2017-10-05T15:02:44Z
dc.date.issued2017
dc.description.abstractThe development of the cerebral cortex requires the coordination of multiple processes ranging from the proliferation of progenitors to the migration and establishment of connectivity of the newborn neurons. Epigenetic regulation carried out by the COREST/LSD1 complex has been identified as a mechanism that regulates the development of pyramidal neurons of the cerebral cortex. We now identify the association of the multifunctional RNA-binding protein SFPQ to LSD1 during the development of the cerebral cortex. In vivo reduction of SFPQ dosage by in utero electroporation of a shRNA results in impaired radial migration of newborn pyramidal neurons, in a similar way to that observed when COREST or LSD1 expressions are decreased. Diminished SFPQ expression also associates to decreased proliferation of progenitor cells, while it does not affect the acquisition of neuronal fate. These results are compatible with the idea that SFPQ, plays an important role regulating proliferation and migration during the development of the cerebral cortex.
dc.description.versionVersión Publicada
dc.format.extent11
dc.identifier.citationaud K, Cánovas J, Lopez CI, Berndt FA, López E, Maass JC, Barriga A, Kukuljan M. SFPQ associates to LSD1 and regulates the migration of newborn pyramidal neurons in the developing cerebral cortex. Int J Dev Neurosci. 2017 Apr;57:1-11. doi: 10.1016/j.ijdevneu.2016.12.006
dc.identifier.urihttp://hdl.handle.net/11447/1705
dc.identifier.urihttp://dx.doi.org/10.1016/j.ijdevneu.2016.12.006
dc.language.isoen_US
dc.publisherElsevier
dc.sourceInternational Journal of Developmental Neuroscience
dc.subjectEpigenetic regulation
dc.subjectNeuronal migration
dc.subjectCorticogenesis
dc.titleSFPQ associates to LSD1 and regulates the migration of newborn pyramidal neurons in the developing cerebral cortex
dc.typeArtículo

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