Immunopathological signatures in multisystem inflammatory syndrome in children and pediatric COVID-19

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dc.contributor.authorSacco , Keith
dc.contributor.authorCastagnoli , Riccardo
dc.contributor.authorVakkilainen, Svetlana
dc.contributor.authorLiu, Can
dc.contributor.authorDelmonte, Ottavia M.
dc.contributor.authorOguz, Cihan
dc.contributor.authorKaplan, Ian M.
dc.contributor.authorAlehashemi, Sara
dc.contributor.authorBurbelo, Peter D.
dc.contributor.authorBhuyan, Farzana
dc.contributor.authorJesus, Adriana A.
dc.contributor.authorDobbs , Kerry
dc.contributor.authorRosen, Lindsey B.
dc.contributor.authorCheng, Aristine
dc.contributor.authorShaw, Elana
dc.contributor.authorVakkilainen, Mikko S.
dc.contributor.authorPala , Francesca
dc.contributor.authorLack, Justin
dc.contributor.authorZhang, Yu
dc.contributor.authorFink, Danielle L.
dc.contributor.authorOikonomou, Vasileios
dc.contributor.authorSnow , Andrew L.
dc.contributor.authorDalgard, Clifton L.
dc.contributor.authorChen, Jinguo
dc.contributor.authorSellers, Brian A.
dc.contributor.authorMontealegre Sanchez, Gina A.
dc.contributor.authorBarron, Karyl
dc.contributor.authorRey-Jurado, Emma
dc.contributor.authorVial, Cecilia
dc.contributor.authorPoli, Cecilia
dc.contributor.authorLicari, Amelia
dc.contributor.authorMontagna, Daniela
dc.contributor.authorMarseglia, Gian Luigi
dc.date.accessioned2022-04-06T20:39:33Z
dc.date.available2022-04-06T20:39:33Z
dc.date.issued2022
dc.descriptionFrancesco Licciardi; Ugo Ramenghi; Valentina Discepolo; Andrea Lo Vecchio; Alfredo Guarino; Eli M. Eisenstein; Luisa Imberti ; Alessandra Sottini; Andrea Biondi; Sayonara Mató; Dana Gerstbacher; Meng Truong; Michael A. Stack; Mary Magliocco; Marita Bosticardo; Tomoki Kawai; Jeffrey J. Danielson; Tyler Hulett; Manor Askenazi; Shaohui Hu; NIAID Immune Response to COVID Group*; Chile MIS-C Group*; Pavia Pediatric; COVID-19 Group*; Jeffrey I. Cohen; Helen C. Su ; Douglas B. Kuhns; Michail S. Lionakis Thomas M. Snyder; Steven M. Holland; Raphaela Goldbach-Mansky; John S. Tsang  and Luigi D. Notarangeloes
dc.description.abstractPediatric Coronavirus Disease 2019 (pCOVID-19) is rarely severe; however, a minority of children infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) might develop multisystem inflammatory syndrome in children (MIS-C), with substantial morbidity. In this longitudinal multi-institutional study, we applied multi-omics (analysis of soluble biomarkers, proteomics, single-cell gene expression and immune repertoire analysis) to profile children with COVID-19 (n= 110) and MIS-C (n= 76), along with pediatric healthy controls (pHCs; n= 76). pCOVID-19 was characterized by robust type I interferon (IFN) responses, whereas prominent type II IFN-dependent and NF-κB-dependent signatures, matrisome activation and increased levels of circulating spike protein were detected in MIS-C, with no correlation with SARS-CoV-2 PCR status around the time of admission. Transient expansion of TRBV11-2 T cell clonotypes in MIS-C was associated with signatures of inflammation and T cell activation. The association of MIS-C with the combination of HLA A*02, B*35 and C*04 alleles suggests genetic susceptibility. MIS-C B cells showed higher mutation load than pCOVID-19 and pHC. These results identify distinct immunopathological signatures in pCOVID-19 and MIS-C that might help better define the pathophysiology of these disorders and guide therapyes
dc.description.versionVersión Publicadaes
dc.identifier.citationSacco, K., Castagnoli, R., Vakkilainen, S. et al. Immunopathological signatures in multisystem inflammatory syndrome in children and pediatric COVID-19. Nat Med (2022). https://doi.org/10.1038/s41591-022-01724-3es
dc.identifier.urihttps://doi.org/10.1038/s41591-022-01724-3es
dc.identifier.urihttp://hdl.handle.net/11447/5952
dc.language.isoenes
dc.subjectImmunopathogenesises
dc.subjectInflammationes
dc.subjectRNA sequencinges
dc.subjectSARS-CoV-2es
dc.subjectViral infectiones
dc.titleImmunopathological signatures in multisystem inflammatory syndrome in children and pediatric COVID-19es
dc.typeArticlees
dcterms.sourceNature Medicinees

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