Cumulative Live Birth Rates Following Stimulation With Corifollitropin Alfa Compared With hp-hMG in a GnRH Antagonist Protocol in Poor Ovarian Responders
Date
2019
Type:
Article
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Abstract
Background: Bologna criteria poor ovarian responders have a very low prognosis.
Although, it has been proposed that LH supplementation could be beneficial in women
with previous hypo-response to FSH. There are no studies comparing the cumulative live
birth rates (LBRs) between corifollitropin alfa (CFA) and highly purified human menopausal
gonadotrophin (hp-hMG).
Objective: To compare cumulative LBRs in Bologna poor ovarian responders
undergoing ovarian stimulation with CFA followed by hp-hMG vs. hp-hMG alone in a
GnRH antagonist protocol.
Design: This is a retrospective cohort study. We included in total 917 poor responders
fulfilling the Bologna criteria for poor ovarian response (POR) at a university-affiliated
tertiary center from January 2011 until March 2017. Patients were administered either
fixed daily doses of 300–450 IU of hp-hMG (group A) or a single dose of 150 µg of CFA
followed by daily injections of ≥300 IU of hp-hMG from Day 8 of stimulation until the day
of ovulation trigger (group B), in a fixed GnRH antagonist protocol.
Results: LBRs after fresh embryo transfer (ET) were similar in group A 71/510 (14%) and
B 42/407 (10%). Cumulative LBR per cycle was significantly higher in group A (16.9%)
compared to group B (11.8%); (P = 0.03). However, logistic regression analysis showed
no association between the type of gonadotropin administered and cumulative LBR. Only
age was significantly associated with cumulative LBR (OR = 0.93, P = 0.007).
Conclusion: Cumulative LBRs are similar in Bologna poor responders stimulated
with CFA followed by hp-hMG compared to hp-hMG monotreatment in an
antagonist protocol
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Citation
Errázuriz J, Romito A, Drakopoulos P, Frederix B, Racca A, De Munck N, Tournaye H, De Vos M and Blockeel C (2019) Cumulative Live Birth Rates Following Stimulation With Corifollitropin Alfa Compared With hp-hMG in a GnRH Antagonist Protocol in Poor Ovarian Responders. Front. Endocrinol. 10:175. doi: 10.3389/fendo.2019.00175
Keywords
Poor responders, Corifollitropin alfa, hp-hMG, Bologna criteria, Cumulative live birth rate