Intracerebral hemorrhage location and outcome among INTERACT2 participants.

Simple item page
dc.contributor.authorINTERACT2 Investigators
dc.contributor.authorDelcourt, Candice
dc.contributor.authorSato, Shoichiro
dc.contributor.authorZhang, Shihong
dc.contributor.authorSandset, Else Charlotte
dc.contributor.authorZheng, Danni
dc.contributor.authorChen, Xiaoying
dc.contributor.authorHackett, Maree L.
dc.contributor.authorArima, Hisatomi
dc.contributor.authorHata, Jun
dc.contributor.authorHeeley, Emma
dc.contributor.authorAl-Shahi Salman, Rustam
dc.contributor.authorRobinson, Thompson
dc.contributor.authorDavies, Leo
dc.contributor.authorLavados, Pablo
dc.contributor.authorLindley, Richard I.
dc.contributor.authorStapf, Christian
dc.contributor.authorChalmers, John
dc.contributor.authorAnderson, Craig
dc.date.accessioned2017-09-12T12:09:27Z
dc.date.available2017-09-12T12:09:27Z
dc.date.issued2017
dc.description.abstractOBJECTIVE: To clarify associations between intracerebral hemorrhage (ICH) location and clinical outcomes among participants of the main phase Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT2). METHODS: Associations between ICH sites and poor outcomes (death [6] or major disability [3-5] of modified Rankin Scale) and European Quality of Life Scale (EQ-5D) utility scores at 90 days were assessed in logistic regression models. RESULTS: Of 2,066 patients included in the analyses, associations were identified between ICH sites and poor outcomes: involvement of posterior limb of internal capsule increased risks of death or major disability (odds ratio [OR] 2.10) and disability (OR 1.81); thalamic involvement increased risks of death or major disability (OR 2.24) and death (OR 1.97). Involvement of the posterior limb of the internal capsule, thalamus, and infratentorial sites were each associated with poor EQ-5D utility score (≤0.7 [median]; OR 1.87, 2.14, and 2.81, respectively). Posterior limb of internal capsule involvement was strongly associated with low scores across all health-related quality of life domains. ICH encompassing the thalamus and posterior limb of internal capsule were associated with death or major disability, major disability, and poor EQ-5D utility score (OR 1.72, 2.26, and 1.71, respectively). CONCLUSION: Poor clinical outcomes are related to ICH affecting the posterior limb of internal capsule, thalamus, and infratentorial sites. The highest association with death or major disability and poor EQ-5D utility score was seen in ICH encompassing the thalamus and posterior limb of internal capsule. CLINICALTRIALSGOV REGISTRATION: NCT00716079.
dc.format.extent7
dc.identifier.citationNeurology. 2017 Apr 11; 88(15): 1408–1414
dc.identifier.urihttp://hdl.handle.net/11447/1671
dc.identifier.urihttp://dx.doi.org/10.1212/WNL.0000000000003771
dc.language.isoen_US
dc.publisherAmerican Academy of Neurology
dc.subjectAntihypertensive Agents
dc.subjectBlood Pressure
dc.subjectCerebral Hemorrhage
dc.subjectDisabled Persons
dc.subjectOutcome Assessment (Health Care)
dc.titleIntracerebral hemorrhage location and outcome among INTERACT2 participants.
dc.typeArtículo

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
HIC location outcome Interact2 Neurology 2017.pdf
Size:
388.15 KB
Format:
Adobe Portable Document Format
Description:
Texto completo
Download

Collections

Artículos Medicina y Ciencias de la Salud

Implementado por OpenGeek Services