Neuroanatomical Comparison of the "Word" and "Picture" Versions of the Free and Cued Selective Reminding Test in Alzheimer's Disease

dc.contributor.authorSlachevsky, Andrea
dc.contributor.authorBarraza, Paulo
dc.contributor.authorHornberger, Michael
dc.contributor.authorMuñoz, Carlos
dc.contributor.authorFlanagan, Emma
dc.contributor.authorHenríquez, Fernando
dc.contributor.authorBravo, Eduardo
dc.contributor.authorFarías, Mauricio
dc.contributor.authorDelgado, Carolina
dc.date.accessioned2022-05-13T15:17:20Z
dc.date.available2022-05-13T15:17:20Z
dc.date.issued2018
dc.description.abstractEpisodic memory tests with cued recall, such as the Free and Cued Selective Reminding Test (FCSRT), allow for the delineation of hippocampal and prefrontal atrophy contributions to memory performance in Alzheimer’s disease (AD). Both Word and Picture versions of the test exist but show different profiles, with the Picture version usually scoring higher across different cohorts. One possible explanation for this divergent performance between the different modality versions of the test might be that they rely on different sets of neural correlates. The current study explores this by contrasting the neural correlates of the Word and Picture versions of the FCSRT with voxel-based morphometry (VBM) in AD and healthy subjects. We predicted that the Picture version would be associated with different cortical regions than the Word version, which might be more hippocampal-centric. When comparing 35 AD patients and 34 controls, AD patients exhibited impairments on both versions of the FCSRT and both groups performed higher in the Picture version. A region of interest analysis based on prior work revealed significant correlations between free recall of either version with atrophy of the temporal pole and hippocampal regions. Thus, contrary to expectations, performance on both the Word and the Picture version of the FCSRT is associated with largely overlapping networks. Free recall is associated with hippocampal volume and might be properly considered as an indicator of hippocampal structural integrity.es
dc.description.versionVersión publicadaes
dc.identifier.citationSlachevsky A, Barraza P, Hornberger M, Muñoz-Neira C, Flanagan E, Henríquez F, Bravo E, Farías M, Delgado C. Neuroanatomical Comparison of the "Word" and "Picture" Versions of the Free and Cued Selective Reminding Test in Alzheimer's Disease. J Alzheimers Dis. 2018;61(2):589-600. doi: 10.3233/JAD-160973.es
dc.identifier.urihttps://doi.org/10.3233/JAD-160973es
dc.identifier.urihttp://hdl.handle.net/11447/6090
dc.language.isoenes
dc.subjectAlzheimer’s diseasees
dc.subjectFCSRT Picture versiones
dc.subjectFCSRT Word versiones
dc.subjectFree and Cued Selective Reminding Testes
dc.subjectBiomarkerses
dc.subjectEpisodic memoryes
dc.subjectHippocampuses
dc.subjectVoxel based morphometryes
dc.titleNeuroanatomical Comparison of the "Word" and "Picture" Versions of the Free and Cued Selective Reminding Test in Alzheimer's Diseasees
dc.typeArticlees
dcterms.sourceJournal of Alzheimer's disease : JAD.es

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