Genetic Background Matters: Population-Based Studies in Model Organisms for Translational Research

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dc.contributor.authorOlguín, Valeria
dc.contributor.authorDurán, Anyelo
dc.contributor.authorLas Heras, Macarena
dc.contributor.authorRubilar, Juan
dc.contributor.authorCubillos, Francisco
dc.contributor.authorOlguín, Patricio
dc.contributor.authorKlein, Andrés
dc.date.accessioned2023-03-20T19:57:55Z
dc.date.available2023-03-20T19:57:55Z
dc.date.issued2022
dc.description.abstractWe are all similar but a bit different. These differences are partially due to variations in our genomes and are related to the heterogeneity of symptoms and responses to treatments that patients exhibit. Most animal studies are performed in one single strain with one manipulation. However, due to the lack of variability, therapies are not always reproducible when treatments are translated to humans. Panels of already sequenced organisms are valuable tools for mimicking human phenotypic heterogeneities and gene mapping. This review summarizes the current knowledge of mouse, fly, and yeast panels with insightful applications for translational research.
dc.description.versionVersión publicada
dc.identifier.citationOlguín, V.; Durán, A.; Las Heras, M.; Rubilar, J.C.; Cubillos, F.A.; Olguín, P.; Klein, A.D. Genetic Background Matters: Population-Based Studies in Model Organisms for Translational Research. Int. J. Mol. Sci. 2022, 23, 7570. https://doi.org/10.3390/ ijms23147570
dc.identifier.doihttps://doi.org/10.3390/ijms23147570
dc.identifier.urihttps://repositorio.udd.cl/handle/11447/7113
dc.language.isoen
dc.subjectDrosophila
dc.subjectSaccharomyces cerevisiae
dc.subjectGene mapping
dc.subjectGenetic background
dc.subjectMouse
dc.subjectPrecision medicine
dc.subjectSystems genetics
dc.subjectTranslational research
dc.titleGenetic Background Matters: Population-Based Studies in Model Organisms for Translational Research
dc.typeArticle
dcterms.accessRightsAcceso abierto
dcterms.sourceInternational journal of molecular sciences.

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