Adrenergic modulation of dexketoprofen antinociception in murine formalin orofacial pain

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dc.contributor.authorMiranda, Hugo
dc.contributor.authorNoriega, Viviana
dc.contributor.authorSierralta, Fernando
dc.contributor.authorPrieto, Juan
dc.date.accessioned2022-06-23T20:08:58Z
dc.date.available2022-06-23T20:08:58Z
dc.date.issued2021
dc.description.abstractNon-steroidal anti-inflammatory drugs (NSAIDs) are widely used in pain whose mechanism of action is the inhibition of cyclooxygenase enzymes (COXs), however, there are evidence of other mechanisms of action, such as the inhibition of substance P, interaction with systems NO, monoaminergic and others. The objective of the present work was to study the participation of -1 (prazosin) and -2 (yohimbine) adrenoceptors antagonists in the antinociception of dexketoprofen, the S (+) enantiomer of ketoprofen. The antinociception evaluation was thru the mice orofacial formalin assay. Dexketoprofen (DEX) induced a dose-related antinociception 3.40 times more potent in phase I than in phase II. Prazosin i.p. decreased of the antinociception of DEX, 2.01 times in phase I and 4.02 times in phase II. Administered i.t. reduced the antinociception 5.30 times in phase I and 6.20 times in phase II. Yohimbine i.p. induced a reduction of the ED50 of 3.40 times in phase I and 4.50 times in phase II, after i.t. administration the reduction was 5.30 times in phase I and 6.20 times in phase II. The mechanism of antinociception induced by DEX is mediated by the activation of α-1 and α-2 adrenergic receptors at supraspinal and spinal levels.es
dc.description.versionVersión publicadaes
dc.identifier.citationMiranda, Hugo & Noriega, Viviana & Sierralta, Fernando & Sotomayor-Zárate, Ramón & Prieto, Juan. (2021). Adrenergic modulation of dexketoprofen antinociception in murine formalin orofacial pain. World Journal of Advanced Research and Reviews. https://doi.org/10.30574/wjarr.2021.9.2.0063es
dc.identifier.urihttps://doi.org/10.30574/wjarr.2021.9.2.0063es
dc.identifier.urihttp://hdl.handle.net/11447/6251
dc.language.isoenes
dc.subjectAdrenergic Modulationes
dc.subjectDexketoprofenes
dc.subjectAntinociceptiones
dc.subjectOrofacial Paines
dc.subjectPrazosines
dc.subjectYohimbinees
dc.titleAdrenergic modulation of dexketoprofen antinociception in murine formalin orofacial paines
dc.typeArticlees
dcterms.sourceWorld Journal of Advanced Research and Reviewses

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