Giant cell arteritis and its mimics: A comparison of three patient cohorts
dc.contributor.author | Koster, Matthew | |
dc.contributor.author | Yeruva, Karthik | |
dc.contributor.author | Crowson, Cynthia S | |
dc.contributor.author | Muratore, Francesco | |
dc.contributor.author | Labarca, Cristian | |
dc.contributor.author | Warrington, Kenneth J | |
dc.date.accessioned | 2021-10-28T14:22:36Z | |
dc.date.available | 2021-10-28T14:22:36Z | |
dc.date.issued | 2020 | |
dc.description.abstract | Objective: To compare temporal artery biopsy (TAB)-positive giant cell arteritis (GCA) to TAB-negative GCA and patients with GCA mimics METHODS: PATIENTS DIAGNOSED WITH TAB-POSITIVE AND TAB-NEGATIVE GCA BETWEEN 1/1/1998 AND 12/31/2013 WERE: retrospectively identified. These two groups were compared to a cohort of patients with TAB performed between 1/1/2009 and 12/31/2010 in which the TAB was negative and alternative diagnosis was provided after a minimum of 6-months of follow-up. Baseline characteristics were compared between groups using chi-square and rank sum tests. Results: 591 study subjects were identified (286 TAB-positive, 110 TAB-negative GCA and 195 TAB-negative GCA mimics) during the respective study periods. Compared to TAB-negative GCA, GCA mimics had similar rates of headache and vision loss but significantly less frequent jaw/limb claudication, arterial bruits and constitutional symptoms, as well as lower platelet levels. Compared to TAB-positive GCA patients, TAB-negative GCA were younger, had shorter time to diagnosis, met fewer 1990 ACR classification criteria and had lower frequencies of polymyalgia rheumatica, jaw claudication and temporal artery abnormalities; but, higher frequency of arm claudication and constitutional symptoms. Among 61 TAB-negative patients with advanced arterial imaging, 43 (69%) had at least one abnormality consistent with GCA. Conclusion: Consideration of alternative diagnoses is requisite in evaluating patients with negative TAB. Advanced imaging assists in identifying occult large-vessel vasculitis and should be employed in all TAB-negative patients with suspicion for GCA. | es |
dc.identifier.citation | Seminars in arthritis and rheumatism 2020 Oct;50(5):923-929 | es |
dc.identifier.uri | https://doi.org/10.1016/j.semarthrit.2020.05.018 | es |
dc.identifier.uri | http://hdl.handle.net/11447/4962 | |
dc.language.iso | en_US | es |
dc.subject | Biopsy | es |
dc.subject | Giant cell | es |
dc.subject | Large-vessel vasculiti | es |
dc.subject | Temporal artery | es |
dc.title | Giant cell arteritis and its mimics: A comparison of three patient cohorts | es |
dc.type | Article | es |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- Giant cell arteritis and its mimics A comparison of three patient cohorts.pdf
- Size:
- 490.15 KB
- Format:
- Adobe Portable Document Format
- Description:
- Texto Completo
License bundle
1 - 1 of 1
No Thumbnail Available
- Name:
- license.txt
- Size:
- 1.71 KB
- Format:
- Item-specific license agreed upon to submission
- Description: