Giant cell arteritis and its mimics: A comparison of three patient cohorts

Simple item page
dc.contributor.authorKoster, Matthew
dc.contributor.authorYeruva, Karthik
dc.contributor.authorCrowson, Cynthia S
dc.contributor.authorMuratore, Francesco
dc.contributor.authorLabarca, Cristian
dc.contributor.authorWarrington, Kenneth J
dc.date.accessioned2021-10-28T14:22:36Z
dc.date.available2021-10-28T14:22:36Z
dc.date.issued2020
dc.description.abstractObjective: To compare temporal artery biopsy (TAB)-positive giant cell arteritis (GCA) to TAB-negative GCA and patients with GCA mimics METHODS: PATIENTS DIAGNOSED WITH TAB-POSITIVE AND TAB-NEGATIVE GCA BETWEEN 1/1/1998 AND 12/31/2013 WERE: retrospectively identified. These two groups were compared to a cohort of patients with TAB performed between 1/1/2009 and 12/31/2010 in which the TAB was negative and alternative diagnosis was provided after a minimum of 6-months of follow-up. Baseline characteristics were compared between groups using chi-square and rank sum tests. Results: 591 study subjects were identified (286 TAB-positive, 110 TAB-negative GCA and 195 TAB-negative GCA mimics) during the respective study periods. Compared to TAB-negative GCA, GCA mimics had similar rates of headache and vision loss but significantly less frequent jaw/limb claudication, arterial bruits and constitutional symptoms, as well as lower platelet levels. Compared to TAB-positive GCA patients, TAB-negative GCA were younger, had shorter time to diagnosis, met fewer 1990 ACR classification criteria and had lower frequencies of polymyalgia rheumatica, jaw claudication and temporal artery abnormalities; but, higher frequency of arm claudication and constitutional symptoms. Among 61 TAB-negative patients with advanced arterial imaging, 43 (69%) had at least one abnormality consistent with GCA. Conclusion: Consideration of alternative diagnoses is requisite in evaluating patients with negative TAB. Advanced imaging assists in identifying occult large-vessel vasculitis and should be employed in all TAB-negative patients with suspicion for GCA.es
dc.identifier.citationSeminars in arthritis and rheumatism 2020 Oct;50(5):923-929es
dc.identifier.urihttps://doi.org/10.1016/j.semarthrit.2020.05.018es
dc.identifier.urihttp://hdl.handle.net/11447/4962
dc.language.isoen_USes
dc.subjectBiopsyes
dc.subjectGiant celles
dc.subjectLarge-vessel vasculities
dc.subjectTemporal arteryes
dc.titleGiant cell arteritis and its mimics: A comparison of three patient cohortses
dc.typeArticlees

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Giant cell arteritis and its mimics A comparison of three patient cohorts.pdf
Size:
490.15 KB
Format:
Adobe Portable Document Format
Description:
Texto Completo
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Artículos Medicina y Ciencias de la Salud

Implementado por OpenGeek Services