Oncogenic role of arsenic exposure in lung cancer: A forgotten risk factor

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dc.contributor.authorSoza, Cristian
dc.contributor.authorBustamante, Eva
dc.contributor.authorCaglevic, Christian
dc.contributor.authorRolfo, Christian
dc.contributor.authorSirera, Rafael
dc.contributor.authorMarsiglia, Hugo
dc.date.accessioned2022-07-06T20:23:21Z
dc.date.available2022-07-06T20:23:21Z
dc.date.issued2019
dc.description.abstractSeveral drinkable water sources worldwide have been highly contaminated with arsenic, which means that an estimated 160 million people have been exposed to this chemical agent. If we analyse exposure by region, we will find a high correlation between arsenic contamination and the incidence of lung cancer (among other malignancies). In order to determine what the risks of these exposures are, we need to understand how this chemical is processed in our body and how it is linked to cancer. In this article we reviewed how biotransformation of ingested arsenic may lead to cancer by modulating the activation of several essential signalling pathways such as EGFR, PI3K/AKT, RTK/Ras/PI3K, JNK/STAT3 and Nrf2-KEAP1; by producing epigenetics modifications and by disrupting normal expression of miRNAs. In order to design effective health policies, educational strategies, decontaminations plans and effective medical treatments are necessary to understand the impact of arsenic pollution and the relevance of the environment in our health.es
dc.description.versionVersión publicadaes
dc.identifier.citationSoza-Ried C, Bustamante E, Caglevic C, Rolfo C, Sirera R, Marsiglia H. Oncogenic role of arsenic exposure in lung cancer: A forgotten risk factor. Crit Rev Oncol Hematol. 2019 Jul;139:128-133. doi:10.1016/j.critrevonc.2019.01.012.es
dc.identifier.urihttps://doi.org/10.1016/j.critrevonc.2019.01.012es
dc.identifier.urihttp://hdl.handle.net/11447/6314
dc.language.isoenes
dc.subjectArsenic / adverse effectses
dc.subjectCarcinogenesis / chemically inducedes
dc.subjectCarcinogenesis / pathologyes
dc.subjectHumanses
dc.subjectIncidencees
dc.subjectLung Neoplasms / chemically inducedes
dc.subjectLung Neoplasms / epidemiologyes
dc.subjectRisk Factorses
dc.titleOncogenic role of arsenic exposure in lung cancer: A forgotten risk factores
dc.typeArticlees
dcterms.sourceCritical Reviews in Oncology/Hematologyes

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