Effects of an Avocado-based Mediterranean Diet on Serum Lipids for Secondary Prevention after Ischemic Stroke Trial (ADD-SPISE)

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dc.contributor.authorOlavarría, Verónica
dc.contributor.authorCampodónico, Paola
dc.contributor.authorVollrath, Valeska
dc.contributor.authorVon Geldern, Paula
dc.contributor.authorVelásquez, Carolina
dc.contributor.authorPávez, Patricia
dc.contributor.authorValente, Bárbara
dc.contributor.authorDonoso, Pamela
dc.contributor.authorGinesta, Alexandra
dc.contributor.authorCavada, Gabriel
dc.contributor.authorMazzon, Enrico
dc.contributor.authorNavia, Víctor
dc.contributor.authorGuzmán, Matías
dc.contributor.authorBrinck, Pablo
dc.contributor.authorLavados, Pablo
dc.date.accessioned2022-03-30T19:41:14Z
dc.date.available2022-03-30T19:41:14Z
dc.date.issued2021
dc.description.abstractBackground: A poor or unhealthy diet is responsible for an important fraction of ischemic stroke risk. Adherence to dietary patterns, such as the Mediterranean diet, rich in monounsaturated fatty acids mainly from olive oil, is associated with a lower stroke risk. Furthermore, lowering low-density cholesterol (LDL-C) levels decreases stroke recurrence. Interestingly, Avocado-substituted diets, which are also rich in monounsaturated fatty acids, significantly decrease LDL cholesterol levels. This study aims to evaluate whether a Mediterranean diet based on Avocados reduces LDL-C compared to a low-fat high-complex carbohydrate diet after 3 months of the intervention in patients who had a recent acute ischemic stroke. The trial will also assess safety and feasibility. Patients and methods: Prospective, randomized open-label, blinded outcome assessment clinical trial. Participants are patients within a month of being admitted with an ischemic stroke, who consent and fulfil the eligibility criteria. Patients are randomly assigned to either diet intervention in a 1:1 ratio on top of the usual secondary prevention treatment. The intervention diet is: A)Avocado-based Mediterranean diet with intake of 1/2 portion of Avocado per day and B)The control diet is a low-fat high-complex carbohydrate diet. The main efficacy outcome is a reduction in plasma LDL-C levels at 3 months of the dietary intervention. Secondary outcomes include changes in the levels of serum lipid profile and serum inflammation markers, safety, and feasibility. A sample size of 200 patients was estimated to provide 80% power and 5% level of significance (10% loss and 5% crossover) to detect a minimum difference of 4.6 mg/dL in LDL-C after 3 months of intervention. Conclusion: We hypothesize that an Avocado-based Mediterranean diet will further reduce the levels of LDL-cholesterol at 3 months compared to the control diet, and that the intervention is safe and feasible.es
dc.description.versionVersión publicadaes
dc.identifier.citationOlavarría VV, Campodónico P, Vollrath V, von Geldern P, Velásquez C, Pavez P, Valente B, Donoso P, Ginesta A, Cavada G, Mazzon E, Navia V, Guzmán M, Brinck P, Lavados PM. Effects of an Avocado-based Mediterranean Diet on Serum Lipids for Secondary Prevention after Ischemic Stroke Trial (ADD-SPISE): Study protocol. Medicine (Baltimore). 2021 Jun 18;100(24):e26425.doi:10.1097/MD.0000000000026425es
dc.identifier.urihttps://doi.org/10.1097/MD.0000000000026425es
dc.identifier.urihttp://hdl.handle.net/11447/5874
dc.language.isoenes
dc.subjectAvocadoes
dc.subjectClinical triales
dc.subjectDietes
dc.subjectIschemic strokees
dc.subjectMediterranean dietes
dc.subjectSecondary preventiones
dc.subjectSerum lipidses
dc.titleEffects of an Avocado-based Mediterranean Diet on Serum Lipids for Secondary Prevention after Ischemic Stroke Trial (ADD-SPISE)es
dc.typeArticlees
dcterms.sourceMedicinees

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