Factores de riesgo socio-demográficos del síndrome cardiopulmonar por hantavirus

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dc.contributor.authorVial, Cecilia
dc.contributor.authorValdivieso, Francisca
dc.contributor.authorCuiza, Analía
dc.contributor.authorDelgado, Iris
dc.contributor.authorRibeiro, Grazielle
dc.contributor.authorLlop, Elena
dc.contributor.authorFerrés, Marcela
dc.contributor.authorRepetto, Gabriela
dc.contributor.authorRiquelme, Raúl
dc.contributor.authorRioseco, María Luisa
dc.contributor.authorCalvo, Mario
dc.contributor.authorMertz, Gregory
dc.contributor.authorVial, Pablo
dc.date.accessioned2020-04-01T15:24:01Z
dc.date.available2020-04-01T15:24:01Z
dc.date.issued2019
dc.description.abstractBackground: Hantavirus cardiopulmonary syndrome (HCPS) is caused by new world hantaviruses, among which Andes hantavirus (ANDV) is endemic to Chile and Southern Argentina. The disease caused by ANDV produces plasma leakage leading to enhanced vascular permeability and has a high case fatality rate (35%), mainly due to respiratory failure, pulmonary edema and myocardial dysfunction, hypoperfusion and shock. Host sociodemographic and genetic factors might influence the course and outcome of the disease. Yet, they have not been thoroughly characterized. Aim: To evaluate sociodemographic factors as risk factors in severity of HCPS. Patients and Methods: Study period: 2004-20013, attending in eight collaborative centers, etiological diagnosis was performed by serology or molecular biology, mild and severe HCPS were compared.139 Chilean patients were analyzed, 64 (46%) with severe disease among which 12 (19 %) died. Results: European ethnicity had 5,1 times higher risk than Amerindian ethnic group to develop a severe HCPS, greater seriousness that was also associated with an urban residence. Conclusion: It was observed that ethnicity and type of residence were significant risk factors for HCPS severity. Hypotheses explaining these findings are discussed.
dc.format.extent5 p.
dc.identifier.citationVial C. Cecilia, Valdivieso R. Francisca, Cuiza V. Analía, Delgado B. Iris, Ribeiro E. Grazielle, Llop R. Elena et al . Factores de riesgo socio-demográficos del síndrome cardiopulmonar por hantavirus. Revista Chilena de Infectología. [Internet]. 2019 Ago [citado 2022 Jul 18] ; 36( 4 ): 428-432. Disponible en: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-10182019000400428&lng=es. http://dx.doi.org/10.4067/S0716-10182019000400428.
dc.identifier.urihttp://hdl.handle.net/11447/3194
dc.identifier.urihttp://dx.doi.org/10.4067/S0716-10182019000400428
dc.language.isoes
dc.relation.projectFuentes de financiamiento: National of Allergy and Infectious Diseases at the National Institutes of Health NIH 5UI9AI045452, Fondo Nacional de Desarrollo Científico y Tecnológico FONDECYT Project Nº 1040155, Nº 11110397 y 1161447
dc.sourceRevista Chilena de Infectología
dc.subjectSusceptibilidad étnica
dc.subjectInfección por hantavirus
dc.subjectSíndrome cardiopulmonar por hantavirus
dc.subjectHantavirus Andes
dc.subjectHantavirus
dc.titleFactores de riesgo socio-demográficos del síndrome cardiopulmonar por hantavirus
dc.typeArticle

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