Gram-positive bacterial infections: research priorities, accomplishments, and future directions of the antibacterial resistance leadership group

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dc.contributor.authorDoernberg, Sarah
dc.contributor.authorLodise, Thomas
dc.contributor.authorThaden, Joshua
dc.contributor.authorMunita, José
dc.contributor.authorCosgrove, Sara
dc.contributor.authorArias, Cesar
dc.contributor.authorBoucher, Helen
dc.contributor.authorCorey, G. Ralph
dc.contributor.authorLowy, Franklin
dc.contributor.authorMurray, Barbara
dc.contributor.authorMiller, Loren
dc.contributor.authorHolland, Thomas
dc.date.accessioned2017-08-30T13:00:24Z
dc.date.available2017-08-30T13:00:24Z
dc.date.issued2017
dc.description.abstractAntimicrobial resistance in gram-positive bacteria remains a challenge in infectious diseases. The mission of the Gram-Positive Committee of the Antibacterial Resistance Leadership Group (ARLG) is to advance knowledge in the prevention, management, and treatment of these challenging infections to improve patient outcomes. Our committee has prioritized projects involving methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE) due to the scope of the medical threat posed by these pathogens. Approved ARLG projects involving gram-positive pathogens include (1) a pharmacokinetics/pharmacodynamics study to evaluate the impact of vancomycin dosing on patient outcome in MRSA bloodstream infection (BSI); (2) defining, testing, and validating innovative assessments of patient outcomes for clinical trials of MRSA-BSI; (3) testing new strategies for "step-down" antibiotic therapy for MRSA-BSI; (4) management of staphylococcal BSIs in neonatal intensive care units; and (5) defining the impact of VRE bacteremia and daptomycin susceptibility on patient outcomes. This article outlines accomplishments, priorities, and challenges for research of infections caused by gram-positive organisms.
dc.format.extent6
dc.identifier.citationClin Infect Dis. 2017 Mar 15;64(suppl_1):S24-S29
dc.identifier.urihttp://hdl.handle.net/11447/1617
dc.identifier.urihttp://dx.doi.org/10.1093/cid/ciw828
dc.language.isoen_US
dc.publisherOxford University Press
dc.subjectClostridium difficile infection
dc.subjectStaphylococcus aureus
dc.subjectbloodstream infection
dc.subjectgram-positive bacteria
dc.subjectvancomycin-resistant enterococci
dc.titleGram-positive bacterial infections: research priorities, accomplishments, and future directions of the antibacterial resistance leadership group
dc.typeArtículo

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