Human hantavirus infections: epidemiology, clinical features, pathogenesis and immunology

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dc.contributor.authorManigold, Tobias
dc.contributor.authorVial, Pablo
dc.date.accessioned2017-04-06T14:34:12Z
dc.date.available2017-04-06T14:34:12Z
dc.date.issued2014
dc.description.abstractIn humans, hantaviruses can cause haemorrhagic fever with renal syndrome (HFRS) or hantavirus cardiopulmonary syndrome (HCPS). Currently it is estimated that 150,000 to 200,000 cases of hantavirus disease occur each year, the majority being reported in Asia. However, human hantavirus infections are increasingly reported in the Americas and Europe. Although many of the underlying pathogenic mechanisms still remain unclear, recent evidence rather argues against a purely immune-mediated pathophysiology of human disease. Despite the high morbidity and case-fatality rates of HFRS and HCPS, respectively, no vaccine or drug is currently proven to be preventive or therapeutic. This review summarises clinical features and current epidemiological findings, as well as concepts regarding the immunology, pathogenesis and intervention strategies of human hantaviral diseases.
dc.format.extent10
dc.identifier.citationSwiss Med Wkly. 2014 Mar 20;144:w13937
dc.identifier.urihttp://hdl.handle.net/11447/1096
dc.identifier.urihttp://dx.doi.org/10.4414/smw.2014.13937
dc.language.isoen_US
dc.publisherEMH Swiss Medical Publishers
dc.subjecthantavirus
dc.subjectHCPS
dc.subjectHFRS
dc.subjectimmunology
dc.subjectpathogenesis
dc.titleHuman hantavirus infections: epidemiology, clinical features, pathogenesis and immunology
dc.typeArtículo

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