Cell Intrinsic and Extrinsic Mechanisms of Caveolin- 1-Enhanced Metastasis

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dc.contributor.authorCampos, América
dc.contributor.authorBurgos-Ravanal, R.
dc.contributor.authorGonzález, M.F.
dc.contributor.authorHuilcamán, R.
dc.contributor.authorLobos-González, Lorena
dc.contributor.authorQuest, AFG.
dc.date.accessioned2019-11-26T20:45:14Z
dc.date.available2019-11-26T20:45:14Z
dc.date.issued2019
dc.description.abstractCaveolin-1 (CAV1) is a scaffolding protein with a controversial role in cancer. This review will initially discuss earlier studies focused on the role as a tumor suppressor before elaborating subsequently on those relating to function of the protein as a promoter of metastasis. Different mechanisms are summarized illustrating how CAV1 promotes such traits upon expression in cancer cells (intrinsic mechanisms). More recently, it has become apparent that CAV1 is also a secreted protein that can be included into exosomes where it plays a significant role in determining cargo composition. Thus, we will also discuss how CAV1 containing exosomes from metastatic cells promote malignant traits in more benign recipient cells (extrinsic mechanisms). This ability appears, at least in part, attributable to the transfer of specific cargos present due to CAV1 rather than the transfer of CAV1 itself. The evolution of how our perception of CAV1 function has changed since its discovery is summarized graphically in a time line figure.
dc.format.extent25 p.
dc.identifier.citationBiomolecules, 2019, vol.9, n°8
dc.identifier.urihttp://hdl.handle.net/11447/2866
dc.language.isoen
dc.subjectCaveolae
dc.subjectCholesterol transport
dc.subjectTumor suppressor
dc.subjectMetastasis promoter
dc.subjectExosomes
dc.titleCell Intrinsic and Extrinsic Mechanisms of Caveolin- 1-Enhanced Metastasis
dc.typeArticle

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