Cxs and Panx- hemichannels in peripheral and central chemosensing in mammals.

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dc.contributor.authorReyes, Edison
dc.contributor.authorCerpa, Verónica
dc.contributor.authorCorvalán, Liliana
dc.contributor.authorRetamal, Mauricio
dc.date.accessioned2017-03-07T15:50:58Z
dc.date.available2017-03-07T15:50:58Z
dc.date.issued2014
dc.descriptionCentro de Fisiología Celular e Integrativa
dc.description.abstractConnexins (Cxs) and Pannexins (Panx) form hemichannels at the plasma membrane of animals. Despite their low open probability under physiological conditions, these hemichannels release signaling molecules (i.e., ATP, Glutamate, PGE2) to the extracellular space, thus subserving several important physiological processes. Oxygen and CO2 sensing are fundamental to the normal functioning of vertebrate organisms. Fluctuations in blood PO2, PCO2 and pH are sensed at the carotid bifurcations of adult mammals by glomus cells of the carotid bodies. Likewise, changes in pH and/or PCO2 of cerebrospinal fluid are sensed by central chemoreceptors, a group of specialized neurones distributed in the ventrolateral medulla (VLM), raphe nuclei, and some other brainstem areas. After many years of research, the molecular mechanisms involved in chemosensing process are not completely understood. This manuscript will review data regarding relationships between chemosensitive cells and the expression of channels formed by Cxs and Panx, with special emphasis on hemichannels.
dc.format.extent13
dc.identifier.citationFront Cell Neurosci. 2014; 8: 123
dc.identifier.urihttp://hdl.handle.net/11447/1009
dc.identifier.urihttp://dx.doi.org/10.3389/fncel.2014.00123
dc.language.isoen_US
dc.publisherFrontiers Research Foundation
dc.subjectGap junctions
dc.subjectCarotid body
dc.subjectGlomus cells
dc.subjectConnexins
dc.subjectAstrocytes
dc.subjecthypoxia
dc.subjectHypercapnia
dc.titleCxs and Panx- hemichannels in peripheral and central chemosensing in mammals.
dc.typeArtículo

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