Evolving resistance among Gram-positive pathogens.

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dc.contributor.authorMunita, José
dc.contributor.authorBayer, Arnold
dc.contributor.authorArias, Cesar
dc.date.accessioned2016-05-23T13:48:04Z
dc.date.available2016-05-23T13:48:04Z
dc.date.issued2015
dc.description.abstractAntimicrobial therapy is a key component of modern medical practice and a cornerstone for the development of complex clinical interventions in critically ill patients. Unfortunately, the increasing problem of antimicrobial resistance is now recognized as a major public health threat jeopardizing the care of thousands of patients worldwide. Gram-positive pathogens exhibit an immense genetic repertoire to adapt and develop resistance to virtually all antimicrobials clinically available. As more molecules become available to treat resistant gram-positive infections, resistance emerges as an evolutionary response. Thus, antimicrobial resistance has to be envisaged as an evolving phenomenon that demands constant surveillance and continuous efforts to identify emerging mechanisms of resistance to optimize the use of antibiotics and create strategies to circumvent this problem. Here, we will provide a broad perspective on the clinical aspects of antibiotic resistance in relevant gram-positive pathogens with emphasis on the mechanistic strategies used by these organisms to avoid being killed by commonly used antimicrobial agents.
dc.identifier.citationMunita JM, Bayer AS, Arias CA. Evolving resistance among Gram-positive pathogens. Clin Infect Dis. 2015 Sep 15;61 Suppl 2(Suppl 2):S48-57.
dc.identifier.urihttp://hdl.handle.net/11447/306
dc.identifier.urihttp://dx.doi.org/10.1093/cid/civ523
dc.language.isoen_US
dc.publisherThe Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America
dc.subjectAntimicrobial resistance
dc.subjectMethicillin-resistant
dc.subjectMultidrug-resistant
dc.subjectPenicillin-resistant
dc.subjectVancomycin-resistant
dc.titleEvolving resistance among Gram-positive pathogens.
dc.typeArtículo

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