Perspective on Clinically-Relevant Antimicrobial Resistant Enterobacterales in Food: Closing the Gaps Using Genomics
Date
2021
Type:
Article
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Abstract
Antimicrobial resistance is one of the most important public health concerns—it
causes 700,000 deaths annually according to the World Health Organization (WHO).
Enterobacterales such as E. coli and Klebsiella pneumoniae, have become resistant
to many relevant antimicrobials including carbapenems and extended spectrum
cephalosporins. These clinically relevant resistant Enterobacterales (CRRE) members
are now globally distributed in the environment including different food types (meats,
produce, dairy). Unlike known foodborne pathogens, CRRE are not usually part of most
food surveillance systems. However, numerous reports of CRRE highlight the importance
of these bacteria in food and have been shown to contribute to the overall crisis of
antimicrobial resistance. This is especially important in the context of carriage of these
pathogens by immuno-compromised individuals. CRRE infections upon consumption of
contaminated food could colonize the human gastrointestinal tract and eventually be a
source of systemic infections such as urinary tract infections or septicemia. While different
aspects need to be considered to elucidate this, whole genome sequencing along with
metadata could be used to understand genomic relationships of CRRE obtained from
foods and humans, including isolates from clinical infections. Once robust scientific data
is available on the role of CRRE in food, countries could move forward to better survey
and control CRRE in food.
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Citation
Díaz-Gavidia C, Álvarez FP, Munita JM, Cortés S and Moreno-Switt AI (2021) Perspective on Clinically-Relevant Antimicrobial Resistant Enterobacterales in Food: Closing the Gaps Using Genomics. Front. Sustain. Food Syst. 5:667504. doi: 10.3389/fsufs.2021.667504
Keywords
Antimicrobial resistance, Genomics, Clinically relevant bacteria, Escherichia coli, Klebsiella pneumoniae, Food safety, Resistant bacteria in food