Associations with health-related quality of life after intracerebral haemorrhage: pooled analysis of INTERACT studies

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dc.contributor.authorDelcourt, Candice
dc.contributor.authorZheng, Danni
dc.contributor.authorChen, Xiaoying
dc.contributor.authorHackett, Maree
dc.contributor.authorArima, Hisatomi
dc.contributor.authorHata, Jun
dc.contributor.authorHeeley, Emma
dc.contributor.authorAl-Shahi Salman, Rustam
dc.contributor.authorWoodward, Mark
dc.contributor.authorHuang, Yining
dc.contributor.authorRobinson, Thompson
dc.contributor.authorLavados, Pablo
dc.contributor.authorLindley, Richard I
dc.contributor.authorStapf, Christian
dc.contributor.authorDavies, Leo
dc.contributor.authorChalmers, John
dc.contributor.authorAnderson, Craig
dc.contributor.authorSato, Shoichiro
dc.contributor.authorINTERACT Investigators
dc.date.accessioned2017-09-12T12:29:51Z
dc.date.available2017-09-12T12:29:51Z
dc.date.issued2017
dc.description.abstractBACKGROUND AND PURPOSE: Limited data exist on health-related quality of life (HRQoL) after intracerebral haemorrhage (ICH). We aimed to determine baseline factors associated with HRQoL among participants of the pilot and main phases of the Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage Trials (INTERACT 1 and 2). METHODS: The INTERACT studies were randomised controlled trials of early intensive blood pressure (BP) lowering in patients with ICH (<6 hours) and elevated systolic BP (150-220 mm Hg). HRQoL was determined using the European Quality of Life Scale (EQ-5D) at 90 days, completed by patients or proxy responders. Binary logistic regression analyses were performed to identify factors associated with poor overall HRQoL. RESULTS: 2756 patients were included. Demographic, clinical and radiological factors associated with lower EQ-5D utility score were age, randomisation outside of China, antithrombotic use, high baseline National Institutes of Health Stroke Scale (NIHSS) score, larger ICH, presence of intraventricular extension and use of proxy responders. High (≥14) NIHSS score, larger ICH and proxy responders were associated with low scores in all five dimensions of the EQ-5D. The NIHSS score had a strong association with poor HRQoL (p<0.001). Female gender and antithrombotic use were associated with decreased scores in dimensions of pain/discomfort and usual activity, respectively. CONCLUSIONS: Poor HRQoL was associated with age, comorbidities, proxy source of assessment, clinical severity and ICH characteristics. The strongest association was with initial clinical severity defined by high NIHSS score.
dc.description.versionVersión enviada
dc.format.extent6
dc.identifier.citationDelcourt C, Zheng D, Chen X, Hackett M, Arima H, Hata J, Heeley E, Al-Shahi Salman R, Woodward M, Huang Y, Robinson T, Lavados PM, Lindley RI, Stapf C, Davies L, Chalmers J, Anderson CS, Sato S; INTERACT Investigators. Associations with health-related quality of life after intracerebral haemorrhage: pooled analysis of INTERACT studies. J Neurol Neurosurg Psychiatry. 2017 Jan;88(1):70-75. doi: 10.1136/jnnp-2016-314414
dc.identifier.urihttp://hdl.handle.net/11447/1673
dc.identifier.urihttp://dx.doi.org/10.1136/jnnp-2016-314414
dc.language.isoen_US
dc.publisherBMJ Publishing Group
dc.sourceJournal of Neurology, Neurosurgery and Psychiatry
dc.subjectCerebral Hemorrhage
dc.subjectQuality of life
dc.subjectHealth
dc.subjectBlood Pressure
dc.titleAssociations with health-related quality of life after intracerebral haemorrhage: pooled analysis of INTERACT studies
dc.typeArtículo

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