A physiological approach to understand the role of respiratory effort in the progression of lung injury in SARS-CoV-2 infection

dc.contributor.author	Cruces, Pablo
dc.contributor.author	Retamal, Jaime
dc.contributor.author	Hurtado, Daniel E.
dc.contributor.author	Erranz, Benjamín
dc.contributor.author	Iturrieta, Pablo
dc.contributor.author	González, Carlos
dc.contributor.author	Díaz, Franco
dc.date.accessioned	2021-11-02T15:25:01Z
dc.date.available	2021-11-02T15:25:01Z
dc.date.issued	2020
dc.description.abstract	Deterioration of lung function during the first week of COVID-19 has been observed when patients remain with insufficient respiratory support. Patient self-inflicted lung injury (P-SILI) is theorized as the responsible, but there is not robust experimental and clinical data to support it. Given the limited understanding of P-SILI, we describe the physiological basis of P-SILI and we show experimental data to comprehend the role of regional strain and heterogeneity in lung injury due to increased work of breathing. In addition, we discuss the current approach to respiratory support for COVID-19 under this point of view	es
dc.identifier.citation	Critical Care (2020) 24:494	es
dc.identifier.uri	https://doi.org/10.1186/s13054-020-03197-7	es
dc.identifier.uri	http://hdl.handle.net/11447/4991
dc.language.iso	en_US	es
dc.subject	Mechanical ventilation	es
dc.subject	SARS-CoV2	es
dc.subject	COVID-19	es
dc.subject	P-SIL	es
dc.subject	Lung strain	es
dc.subject	Work of breathing	es
dc.title	A physiological approach to understand the role of respiratory effort in the progression of lung injury in SARS-CoV-2 infection	es
dc.type	Article	es

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