Vancomycin Presoaking of the Graft Appears to Prevent Infection After Anterior Cruciate Ligament Reconstruction: A Systematic Review and Meta-analysis

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dc.contributor.authorFigueroa, Francisco
dc.contributor.authorFigueroa, David
dc.contributor.authorCalvo, Rafael
dc.contributor.authorVaisman, Alex
dc.contributor.authorNúñez, Marilaura
dc.contributor.authorPutnis, Sven
dc.date.accessioned2022-01-17T16:02:31Z
dc.date.available2022-01-17T16:02:31Z
dc.date.issued2021
dc.description.abstractBackground: Vancomycin presoaking of the graft has been shown to decrease infection rates in some case series of anterior cruciate ligament (ACL) reconstruction. Purpose: We sought to substantiate the efficacy of vancomycin presoaked grafts for the prevention of infection after ACL reconstruction. Methods: We performed a systematic review of Medline and OVID to assess the incidence of postoperative infection in studies comparing patients undergoing ACL reconstruction with the use of vancomycin presoaked ACL grafts and a control group of patients undergoing ACL reconstruction without the use of presoaked grafts. The efficacy of vancomycin presoaking was calculated using the Agresti-Coull confidence interval. Relative risk (RR) was calculated for every study and the total sample. Results: The 11 studies that met inclusion criteria comprised 24,298 patients. In patients with vancomycin presoaking of the graft, 1 infection was reported in 8764 cases (0.01% rate). In the studies with control groups that did not have vancomycin presoaked grafts, there were 125 infections in 15,534 ACL reconstructions (0.8% rate). The efficacy of vancomycin presoaking in preventing infection after ACL reconstruction was 99.9% (0.999%–1.000% CI). The overall RR obtained was 0.07 (0.03–0.16 CI). All included studies were retrospective cohort studies (level III). Conclusions: Vancomycin presoaking of the graft has been shown to decrease infection rates after ACL reconstruction in studies of low evidence level. This suggests the need for prospective randomized controlled trials addressing this issue so that recommendations on the routine use of vancomycin presoaking of ACL grafts can be made with confidence.es
dc.description.versionVersión publicadaes
dc.identifier.citationFigueroa F, Figueroa D, Calvo R, Vaisman A, Nuñez M, Putnis S. Vancomycin Presoaking of the Graft Appears to Prevent Infection After Anterior Cruciate Ligament Reconstruction: A Systematic Review and Meta-analysis. HSS Journal®. 2022;18(1):138-144. doi:10.1177/15563316211011682es
dc.identifier.urihttps://doi.org/10.1177/15563316211011682es
dc.identifier.urihttp://hdl.handle.net/11447/5465
dc.language.isoenes
dc.subjectACL reconstructiones
dc.subjectinfectiones
dc.subjectvancomycines
dc.subjectanterior cruciate ligamentes
dc.subjectpreventiones
dc.titleVancomycin Presoaking of the Graft Appears to Prevent Infection After Anterior Cruciate Ligament Reconstruction: A Systematic Review and Meta-analysises
dc.typeArticlees
dcterms.sourceHSS Journal: The Musculoskeletal Journal of Hospital for Special Surgeryes

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