Postadmixture Selection On Chileans Targets Haplotype Involved In Pigmentation, Thermogenesis And Immune Defense Against Pathogens

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dc.contributor.authorVicuña, Lucas
dc.contributor.authorKlimenkova, Olga
dc.contributor.authorNorambuena, Tomás
dc.contributor.authorMartínez, Felipe
dc.contributor.authorShchur, Vladimir
dc.contributor.authorEyheramendy, Susana
dc.contributor.authorFernández, Mario I.
dc.date.accessioned2021-07-29T17:31:31Z
dc.date.available2021-07-29T17:31:31Z
dc.date.issued2020-06
dc.description.abstractDetection of positive selection signatures in populations around the world is helping to uncover recent human evolutionary history as well as the genetic basis of diseases. Most human evolutionary genomic studies have been performed in European, African, and Asian populations. However, populations with Native American ancestry have been largely underrepresented. Here, we used a genome-wide local ancestry enrichment approach complemented with neutral simulations to identify postadmixture adaptations underwent by admixed Chileans through gene flow from Europeans into local Native Americans. The top significant hits (P=2.4x10(-7)) are variants in a region on chromosome 12 comprising multiple regulatory elements. This region includes rs12821256, which regulates the expression of KITLG, a well-known gene involved in lighter hair and skin pigmentation in Europeans as well as in thermogenesis. Another variant from that region is associated with the long noncoding RNA RP11-13A1.1, which has been specifically involved in the innate immune response against infectious pathogens. Our results suggest that these genes were relevant for adaptation in Chileans following the Columbian exchange.es
dc.identifier.citationGenome Biology And Evolution, 2020 june, vol.12(8), pp. 1459-1470es
dc.identifier.urihttps://doi.org/10.1093/gbe/evaa136es
dc.identifier.urihttp://hdl.handle.net/11447/4212
dc.language.isoenes
dc.subjectAdaptationes
dc.subjectGenetic ancestryes
dc.subjectAdmixturees
dc.subjectGene flowes
dc.subjectGenetic driftes
dc.titlePostadmixture Selection On Chileans Targets Haplotype Involved In Pigmentation, Thermogenesis And Immune Defense Against Pathogenses
dc.typeArticlees

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