Central obesity and not age increases skeletal muscle lipids, without influencing lean body mass and strength

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dc.contributor.authorde la Maza, María
dc.contributor.authorHirsch, Sandra
dc.contributor.authorJara, Natalia
dc.contributor.authorLeiva, Laura
dc.contributor.authorBarrera, Gladys
dc.contributor.authorSilva, Claudio
dc.contributor.authorPañella, Loreto
dc.contributor.authorHenríquez, Sandra
dc.contributor.authorBunout, Daniel
dc.date.accessioned2017-05-05T15:58:06Z
dc.date.available2017-05-05T15:58:06Z
dc.date.issued2015
dc.description.abstractBACKGROUND/AIMS: To measure skeletal muscle lipid infiltration, its association with insulin resistance (IR) lean mass and function, in Chilean men differing in age and body composition. Our hypothesis was that muscle lipid accumulation would be higher among older and heavier individuals and this would deteriorate insulin sensitivity (IS) and decrease muscle mass and function, both features of the ageing process. METHODS: Healthy men (38 < 55 and 18 > 65 years), underwent anthropometric measurements, body composition assessment through radiologic densitometry, Nuclear Magnetic Resonance spectroscopy at the tibialis anterioris muscle to measure intra (IMCL) and extramyocellular lipids (EMCL), quadriceps and handgrip strength, 12 minute walking distance and serum biochemistry (haemoglobin, lipoproteins, creatinine, ultrasensitive C Reactive Protein, fasting and post glucose insulin and glucose concentrations, to assess IS). Physical activity was estimated by actigraphy. RESULTS: 23 men were eutrophic, 26 were overweight and 7 were obese and mostly sedentary, independent of age. Both IMCL and EMCL were higher in overweight/ obese men. Abdominal fat was negatively associated with IS and positively correlated with muscle lipid accretion (both IMCL and EMCL), but not with age. As expected, older individuals had lower muscle mass and strength, but not more adipose tissue nor intramyocellular lipids, yet were more glucose intolerant. CONCLUSIONS: central obesity was associated with IMCL and EMCL infiltration and IR. This type of lipid accretion was not related with ageing nor age-related sarcopenia. Older individuals were more glucose intolerant, which was explained by a decrease of insulin secretion more than adiposity-related IR.
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dc.identifier.citationde la Maza MP, Hirsch S, Jara N, Leiva L, Barrera G, Silva C, Pañella L, Henríquez S, Bunout D. Central obesity and not age increases skeletal muscle lipids, without influencing lean body mass and strength. Nutr Hosp. 2014 Sep 12;31(3):1134-41
dc.identifier.urihttp://hdl.handle.net/11447/1198
dc.identifier.urihttp://dx.doi.org/10.3305/nh.2015.31.3.7979
dc.language.isoen_US
dc.publisherGrupo Arán
dc.subjectIntramyocellular lipids (IMCL)
dc.subjectExtramyocellular lipids (EMCL)
dc.subjectInsulin resistance
dc.subjectCentral adiposity
dc.subjectAgeing
dc.subjectSkeletal muscle lipid depots
dc.titleCentral obesity and not age increases skeletal muscle lipids, without influencing lean body mass and strength
dc.typeArtículo

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