Norovirus compared to other relevant etiologies of acute gastroenteritis among families from a semirural county in Chile

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dc.contributor.authorLucero, Yalda
dc.contributor.authorLagomarcino, Anne J.
dc.contributor.authorEspinoza, Mónica
dc.contributor.authorKawakami, Nanami
dc.contributor.authorMamani, Nora
dc.contributor.authorHuerta, Nicole
dc.contributor.authorCanto, Felipe del
dc.contributor.authorFarfán, Mauricio
dc.contributor.authorSawaguchi, Yoshihiro
dc.contributor.authorGeorge, Sergio
dc.contributor.authorO’Ryan, Miguel
dc.date.accessioned2021-07-13T19:29:51Z
dc.date.available2021-07-13T19:29:51Z
dc.date.issued2020
dc.description.abstractObjective: To determine the dynamics of norovirus disease, a major cause of acute gastroenteritis (AGE), compared to other relevant etiologies, among families living in a lower middle income area. Study design :Families with three or more members and with one or more healthy children <24 months of age were followed for 1–2 years to detect any AGE. Stool samples were tested for viral and bacterial pathogens and a questionnaire was completed for those with norovirus or rotavirus AGE. Results: Between April and June 2016, 110 families were enrolled, with 103 of them completing ≥12 months of follow-up. A total of 159 family AGE episodes were detected, mostly affecting one individual (92%). At least one pathogen was detected in 56% (94/169) of samples, of which 75/94 (80%) were sole infections. Norovirus was most common (n = 26), followed closely by enteropathogenic Escherichia coli (EPEC) (n = 25), rotavirus (n = 24), and astrovirus (n = 23). The annual incidence of family AGE was 0.77, and 0.12 for norovirus. Most norovirus AGE occurred in children <4 years old (96%). Only 13/159 (8%) index AGE cases resulted in a secondary case, of which four were associated with norovirus. The majority of norovirus strains were GII (85%), with a mild predominance of GII.4 (9/26; 35%); most norovirus isolates (69%) were recombinants. Conclusions: The family incidence of AGE in this lower middle income community was nearly one episode per year, mostly caused by viruses, specifically norovirus closely followed by rotavirus and astrovirus. Norovirus infections primarily affected children <4 years old and secondary cases were uncommon.es
dc.format.extent8 p.es
dc.identifier.citationInternational Journal of Infectious Diseases Volume 101, December 2020, Pages 353-360es
dc.identifier.urihttps://doi.org/10.1016/j.ijid.2020.10.013es
dc.identifier.urihttp://hdl.handle.net/11447/4170
dc.language.isoenes
dc.subjectNoroviruses
dc.subjectRotaviruses
dc.subjectAcute gastroenteritises
dc.subjectGenotypeses
dc.titleNorovirus compared to other relevant etiologies of acute gastroenteritis among families from a semirural county in Chilees
dc.typeArticlees

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