Spatial Navigation Is Distinctively Impaired in Persistent Postural Perceptual Dizziness

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dc.contributor.authorBreinbauer, Hayo
dc.contributor.authorContreras, María Daniela
dc.contributor.authorLira, Juan Pablo
dc.contributor.authorGuevara, Claudia
dc.contributor.authorCastillo, Leslie
dc.contributor.authorRuëdlinger, Katherine
dc.contributor.authorMuñoz, Daniel
dc.contributor.authorDélano, Paul
dc.date.accessioned2020-03-09T14:25:14Z
dc.date.available2020-03-09T14:25:14Z
dc.date.issued2020
dc.description.abstractObjective: To determine whether performance in a virtual spatial navigational task is poorer in persistent postural perceptual dizziness (PPPD) patients than in healthy volunteers and patients suffering other vestibular disorders. Methods: Subjects were asked to perform three virtual Morris water maze spatial navigational tasks: (i) with a visible target, (ii) then with an invisible target and a fixed starting position, and finally (iii) with an invisible target and random initial position. Data were analyzed using the cumulative search error (CSE) index. Results: While all subjects performed equally well with a visible target, the patients with PPPD (n = 19) performed poorer (p < 0.004) in the invisible target/navigationally demanding tasks (CSE median of 8) than did the healthy controls (n = 18; CSE: 3) and vestibular controls (n = 19; CSE: 4). Navigational performance in the most challenging setting allowed us to discriminate PPPD patients from controls with an area under the receiver operating characteristic curve of 0.83 (sensitivity 78.1%; specificity 83.3%). PPPD patients manifested more chaotic and disorganized search strategies, with more dispersion in the navigational pool than those of the non-PPPD groups (standard distance deviation of 0.97 vs. 0.46 in vestibular controls and 0.20 in healthy controls; p < 0.001). Conclusions: While all patients suffering a vestibular disorder had poorer navigational abilities than healthy controls did, patients with PPPD showed the worst performance, to the point that this variable allowed the discrimination of PPPD from non-PPPD patients. This distinct impairment in spatial navigation abilities offers new insights into PPPD pathophysiology and may also represent a new biomarker for diagnosing this entity.
dc.identifier.citationFront Neurol. 2019; 10: 1361.
dc.identifier.urihttp://hdl.handle.net/11447/3123
dc.identifier.urihttps://doi.org/10.3389/fneur.2019.01361
dc.language.isoen
dc.publisherFrontiers Research Foundation
dc.subjectDizziness
dc.subjectFunctional dizziness
dc.subjectPersistent postural perceptual dizziness
dc.subjectSpatial navigation
dc.subjectMorris water maze
dc.titleSpatial Navigation Is Distinctively Impaired in Persistent Postural Perceptual Dizziness
dc.typeArticle

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