Clinical performance of endobronchial ultrasound‐guided transbronchial needle aspiration for assessing programmed death ligand‐1 expression in nonsmall cell lung cancer

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dc.contributor.authorBiswas, Abhishek
dc.contributor.authorLeon, Marino
dc.contributor.authorDrew, Peter
dc.contributor.authorFernández‐Bussy, Sebastián
dc.contributor.authorFurtado, Larissa
dc.contributor.authorJantz, Michael
dc.contributor.authorMehta, Hiren
dc.date.accessioned2019-07-09T15:09:18Z
dc.date.available2019-07-09T15:09:18Z
dc.date.issued2018
dc.description.abstractBackground: Pembrolizumab was recently approved as a first line agent for metastatic NSCLC in patients with high programmed death-ligand 1 (PD-L1) expression. Objetives: Since a significant portion of lung cancer is diagnosed by endobronchial ultrasound-guided transbronchial needle aspiration (EBUS TBNA); there is a need for PD-L1 testing in these specimens. However, to date few studies have evaluated performance of cytology specimens from EBUS TBNA for PD-L1 analysis. Methods: Patients who had a diagnosis of NSCLC and in whom ancillary testing, i.e., next generation sequencing (NGS), anaplastic lymphoma kinase (ALK), and PD-L1 expression was requested between January and May 2017 were reviewed. RESULTS: Fifty of the 112 patients reviewed had the diagnosis of NSCLC for which ancillary testing was requested. Twelve patients (24%) had squamous cell carcinoma, twenty-seven had adenocarcinoma (54%), five had NSCLC favor adenocarcinoma (10%), two had NSCLC favor squamous cell cancer (4%), and four had NSCLC not otherwise specified (NOS) (8%). Size of the lymph nodes or lesion sampled ranged from 10 to 50 mm. Four (8%) patients had insufficient number of tumor cells in the cell block for any of the ancillary molecular testing. Forty-one (82%) patients had an adequate sample for all three ancillary tests. Satisfactory results for PD-L1 expression for all cases was 86% with 14 (32%) patients having levels of PD-L1 expression >50%. CONCLUSION: EBUS TBNA is effective and has a high proportion of satisfactory results for testing PD-L1 expression on tumor cells in addition to NGS and ALK FISH.
dc.identifier.citationDiagn Cytopathol. 2018 May;46(5):378-383. doi: 10.1002/dc.23900.
dc.identifier.urihttp://hdl.handle.net/11447/2515
dc.identifier.uridoi: 10.1002/dc.23900.
dc.language.isoen
dc.publisherWiley Periodicals, Inc.
dc.subjectPD-L1
dc.subjectEndobronchial ultrasound
dc.subjectImmunotherapy
dc.subjectNonsmall cell lung cancer
dc.subjectPembrolizumab
dc.titleClinical performance of endobronchial ultrasound‐guided transbronchial needle aspiration for assessing programmed death ligand‐1 expression in nonsmall cell lung cancer
dc.typeArticle

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