Lactadherin: From a Well-Known Breast Tumor Marker to a Possible Player in Extracellular Vesicle-Mediated Cancer Progression

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dc.contributor.authorDurán, Eduardo
dc.contributor.authorVera, Tamara
dc.contributor.authorLobos-González, Lorena
dc.date.accessioned2022-11-17T15:33:58Z
dc.date.available2022-11-17T15:33:58Z
dc.date.issued2022
dc.description.abstractLactadherin is a secreted glycoprotein associated with the milk fat globule membrane, which is highly present in the blood and in the mammary tissue of lactating women. Several biological functions have been associated with this protein, mainly attributable to its immunomodulatory role promoting phagocyte-mediated clearance of apoptotic cells. It has been shown that lactadherin also plays important roles in cell adhesion, the promotion of angiogenesis, and tissue regeneration. On the other hand, this protein has been used as a marker of breast cancer and tumor progression. Recently, high levels of lactadherin has been associated with poor prognosis and decreased survival, not only in breast cancer, but also in melanoma, ovarian, colorectal, and other types of cancer. Although the mechanisms responsible for the tumor-promoting effects attributed to lactadherin have not been fully elucidated, a growing body of literature indicates that lactadherin could be a promising therapeutic target and/or biomarker for breast and other tumors. Moreover, recent studies have shown its presence in extracellular vesicles derived from cancer cell lines and cancer patients, which was associated with cancer aggressiveness and worse prognosis. Thus, this review will focus on the link between lactadherin and cancer development and progression, its possible use as a cancer biomarker and/or therapeutic target, concluding with a possible role of this protein in cellular communication mediated by extracellular vesicles.vo model for surgical resection procedures in cancer research.es
dc.description.versionVersión publicadaes
dc.identifier.citationDurán-Jara E, Vera-Tobar T, Lobos-González LL. Lactadherin: From a Well-Known Breast Tumor Marker to a Possible Player in Extracellular Vesicle-Mediated Cancer Progression. Int J Mol Sci. 2022 Mar 31;23(7):3855. doi: 10.3390/ijms23073855es
dc.identifier.urihttps://doi.org/10.3390/ijms23073855es
dc.identifier.urihttp://hdl.handle.net/11447/6684
dc.language.isoenes
dc.subjectBreast cancees
dc.subjectExosomeses
dc.subjectLactadherines
dc.subjectExtracellular vesicleses
dc.titleLactadherin: From a Well-Known Breast Tumor Marker to a Possible Player in Extracellular Vesicle-Mediated Cancer Progressiones
dc.typeArticlees
dcterms.sourceInternational journal of molecular scienceses

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