Knowledge, attitudes, and practices regarding hantavirus disease and acceptance of a vaccine trial in rural communities of southern Chile

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dc.contributor.authorValdivieso, Francisca
dc.contributor.authorGonzalez, Claudia
dc.contributor.authorNajera, Manuel
dc.contributor.authorOlea, Andrea
dc.contributor.authorCuiza, Analía
dc.contributor.authorAguilera, Ximena
dc.contributor.authorMertz, Gregory
dc.date.accessioned2017-10-10T18:54:03Z
dc.date.available2017-10-10T18:54:03Z
dc.date.issued2016
dc.description.abstractAndes hantavirus cardiopulmonary syndrome, transmitted by Oligoryzomys longicaudatus, has no approved treatment, a case fatality rate of 35%, and documented person-to-person transmission. An Andes vaccine, highly needed for prevention, is in development. We aimed to evaluate knowledge, attitudes and practices (KAP) regarding hantavirus disease and willingness to participate in a future Andes vaccine trials through a cross sectional face-to-face oral survey of a randomly selected adult sample from 2 rural communes in southern Chile. Human subjects approval was obtained from our institutional IRBs, and participants signed informed consent. We enrolled 319 subjects from Corral and 321 from Curarrehue; 98% had heard about hantavirus disease and its reservoir but only half knew about transmission, symptoms and prevention. Participants fear the disease but are only partially aware of their own risk. One third of participants reported presence of rodents inside their homes. Despite moderate confidence in their health system, most subjects perceived vaccines as beneficial, and 93% would accept an approved hantavirus vaccine. Half would agree to participate in a vaccine trial and 29% would allow their children to participate. Motivations to participate were mainly altruistic, while risk perception was the main reason for declining. Knowledge about hantavirus disease and prevention practices require reinforcement, and a vaccine trial seems feasible in these populations.
dc.format.extent8
dc.identifier.citationHuman Vaccines & Immunotherapeutics Volume 13, 2017, Issue 4, pages 808-815
dc.identifier.urihttp://hdl.handle.net/11447/1716
dc.identifier.urihttp://dx.doi.org/10.1080/21645515.2016.1250989
dc.language.isoen_US
dc.publisherTaylor & Francis Online
dc.subjectAndes virus
dc.subjectHantavirus
dc.subjecthantavirus cardiopulmonary syndrome
dc.subjecthantavirus pulmonary syndrome
dc.subjecthealth knowledge
dc.subjectattitudes
dc.subjectpractice
dc.subjectvaccines
dc.titleKnowledge, attitudes, and practices regarding hantavirus disease and acceptance of a vaccine trial in rural communities of southern Chile
dc.typeArtículo

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