Sepsis progression to multiple organ dysfunction in carotid chemo/baro-denervated rats treated with lipopolysaccharide

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dc.contributor.authorNardocci, Gino
dc.contributor.authorMartín, Aldo
dc.contributor.authorAbarzúa, Sebastián
dc.contributor.authorRodríguez, Jorge
dc.contributor.authorSimon, Felipe
dc.contributor.authorReyes, Edison
dc.contributor.authorAcuña-Castillo, Claudio
dc.contributor.authorNavarro, Cristina
dc.contributor.authorCortés, Paula
dc.contributor.authorFernández, Ricardo
dc.date.accessioned2016-05-19T13:51:26Z
dc.date.available2016-05-19T13:51:26Z
dc.date.issued2015
dc.descriptionCentro de Fisiología Celular e Integrativa
dc.description.abstractSepsis progresses to multiple organ dysfunction (MOD) due to the uncontrolled release of inflammatory mediators. Carotid chemo/baro-receptors could play a protective role during sepsis. In anesthetized male rats, we measured cardiorespiratory variables and plasma TNF-α, glucocorticoids, epinephrine, and MOD marker levels 90min after lipopolysaccharide (LPS) administration in control (SHAM surgery) and bilateral carotid chemo/baro-denervated (BCN) rats. BCN prior to LPS blunted the tachypneic response and enhanced tachycardia and hypotension. BCN-LPS rats also showed blunted plasma glucocorticoid responses, boosted epinephrine and TNF-α responses, and earlier MOD onset with a lower survival time compared with SHAM-LPS rats. Consequently, the complete absence of carotid chemo/baro-sensory function modified the neural, endocrine and inflammatory responses to sepsis. Thus, carotid chemo/baro-receptors play a protective role in sepsis.
dc.identifier.citationNardocci G, Martin A, Abarzúa S, Rodríguez J, Simon F, Reyes EP, Acuña-Castillo C, Navarro C, Cortes PP, Fernández R. Sepsis progression to multiple organ dysfunction in carotid chemo/baro-denervated rats treated with lipopolysaccharide. J Neuroimmunol. 2015 Jan 15;278:44-52.
dc.identifier.urihttp://hdl.handle.net/11447/278
dc.identifier.urihttp://dx.doi.org/10.1016/j.jneuroim.2014.12.002
dc.language.isoen_US
dc.publisherElsevier B.V.
dc.subjectBilateral carotid/sinus neurotomy
dc.subjectCarotid body
dc.subjectEpinephrine
dc.subjectGlucocorticoids
dc.subjectMultiple organ dysfunction
dc.subjectSepsis
dc.subjectTNF-α
dc.subjectTissue damage
dc.titleSepsis progression to multiple organ dysfunction in carotid chemo/baro-denervated rats treated with lipopolysaccharide
dc.typeArtículo

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