Mechanisms of antibiotic resistance in enterococci

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dc.contributor.authorMiller, William
dc.contributor.authorMunita, José
dc.contributor.authorArias, Cesar
dc.date.accessioned2017-04-05T14:31:15Z
dc.date.available2017-04-05T14:31:15Z
dc.date.issued2014
dc.description.abstractMultidrug-resistant (MDR) enterococci are important nosocomial pathogens and a growing clinical challenge. These organisms have developed resistance to virtually all antimicrobials currently used in clinical practice using a diverse number of genetic strategies. Due to this ability to recruit antibiotic resistance determinants, MDR enterococci display a wide repertoire of antibiotic resistance mechanisms including modification of drug targets, inactivation of therapeutic agents, overexpression of efflux pumps and a sophisticated cell envelope adaptive response that promotes survival in the human host and the nosocomial environment. MDR enterococci are well adapted to survive in the gastrointestinal tract and can become the dominant flora under antibiotic pressure, predisposing the severely ill and immunocompromised patient to invasive infections. A thorough understanding of the mechanisms underlying antibiotic resistance in enterococci is the first step for devising strategies to control the spread of these organisms and potentially establish novel therapeutic approaches.
dc.format.extent29
dc.identifier.citationExpert Rev Anti Infect Ther. 2014 October ; 12(10): 1221-1236
dc.identifier.urihttp://hdl.handle.net/11447/1089
dc.identifier.urihttp://dx.doi.org/10.1586/14787210.2014.956092
dc.language.isoen_US
dc.publisherInforma
dc.subjectantimicrobial resistance
dc.subjectenterococcus
dc.subjectmechanisms of resistance
dc.subjectvancomycin-resistant enterococci
dc.titleMechanisms of antibiotic resistance in enterococci
dc.typeArtículo

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