Pituitary suppression protocol among Bologna poor responders undergoing ovarian stimulation using corifollitropin alfa: does it play any role?

Simple item page
dc.contributor.authorErrázuriz, Joaquín
dc.contributor.authorDrakopoulos, Panagiotis
dc.contributor.authorPening, David
dc.contributor.authorRacca, Annalisa
dc.contributor.authorRomito, Alessia
dc.contributor.authorMunck, Nelke De
dc.contributor.authorTournaye, Herman
dc.contributor.authorVos, MichelDe
dc.contributor.authorBlockeel, Christophe
dc.date.accessioned2022-07-07T15:39:38Z
dc.date.available2022-07-07T15:39:38Z
dc.date.issued2019
dc.description.abstractResearch question: Does the type of pituitary suppression protocol influence cumulative live birth rate (LBR) in Bologna poor responders treated with corifollitropin alfa (CFA)? Design: Retrospective cohort analysis including poor responder patients fulfilling the Bologna criteria who underwent their first intracytoplasmic sperm injection cycle using a CFA-based ovarian stimulation protocol between 2011 and 2017. The starting dose of CFA was 150 µg. The primary outcome was cumulative LBR, defined as the first delivery of a live born resulting from the fresh and all the subsequent frozen embryo transfers. Results: A total of 717 cycles were divided into three groups: A (gonadotrophin-releasing hormone [GnRH] antagonist protocol, n = 407), B (long GnRH agonist protocol, n = 224) and C (short GnRH agonist protocol, n = 86). Cumulative LBR did not significantly differ between groups (20.1% versus 17.4% versus 14.0%; P = 0.35). Significantly more patients in Group A had supernumerary embryos cryopreserved (28.3% versus 18.4% versus 11.6%; P < 0.001). Days of additional highly purified human menopausal gonadotrophin 300 IU injections following CFA were significantly different between Groups A, B and C (3 versus 5 versus 3 days; P < 0.001). Multivariate logistic regression analysis showed that the number of oocytes retrieved remained an independent predictive factor (odds ratio 1.23, 95% confidence interval 1.16-1.31) for cumulative LBR. Conclusions: Poor responders according to the Bologna criteria in whom CFA is used for ovarian stimulation had comparable cumulative LBR, irrespective of the type of pituitary suppression. An increase in number of oocytes retrieved is an independent variable related to cumulative LBR.es
dc.description.versionVersión Publicadaes
dc.identifier.citationErrázuriz J, Drakopoulos P, Pening D, Racca A, Romito A, De Munck N, Tournaye H, De Vos M, Blockeel C. Pituitary suppression protocol among Bologna poor responders undergoing ovarian stimulation using corifollitropin alfa: does it play any role? Reprod Biomed Online. 2019 Jun;38(6):1010-1017. doi: 10.1016/j.rbmo.2018.12.030.es
dc.identifier.urihttps://doi.org/10.1016/j.rbmo.2018.12.030es
dc.identifier.urihttp://hdl.handle.net/11447/6318
dc.language.isoenes
dc.subjectBologna criteriaes
dc.subjectCorifollitropin alfaes
dc.subjectCumulative live birth ratees
dc.subjectPoor responderses
dc.titlePituitary suppression protocol among Bologna poor responders undergoing ovarian stimulation using corifollitropin alfa: does it play any role?es
dc.typeArticlees
dcterms.sourceReproductive BioMedicine Onlinees

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
1-s2.0-S147264831830659X-main.pdf
Size:
479.5 KB
Format:
Adobe Portable Document Format
Description:
Texto completo
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Artículos Medicina y Ciencias de la Salud

Implementado por OpenGeek Services