Safety of the intravenous administration of neurotensin-polyplex nanoparticles in BALB/c mice

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dc.contributor.authorHernandez, Maria
dc.contributor.authorRembao, Jesus
dc.contributor.authorHernandez-Baltazar, Daniel
dc.contributor.authorCastillo-Rodriguez, Rosa
dc.contributor.authorTellez-Lopez, Victor
dc.contributor.authorFlores-Martinez, Yazmin
dc.date.accessioned2017-03-13T19:54:17Z
dc.date.available2017-03-13T19:54:17Z
dc.date.issued2014
dc.descriptionCentro de Medicina Regenerativa
dc.description.abstractNeurotensin (NTS)-polyplex is a gene nanocarrier that has potential nanomedicine-based applications for the treatment of Parkinson's disease and cancers of cells expressing NTS receptor type 1. We assessed the acute inflammatory response to NTS-polyplex carrying a reporter gene in BALB/c mice. The intravenous injection of NTS-polyplex caused the specific expression of the reporter gene in gastrointestinal cells. Six hours after an intravenous injection of propidium iodide labeled-NTS-polyplex, fluorescent spots were located in the cells of the organs with a mononuclear phagocyte system, suggesting NTS-polyplex clearance. In contrast to lipopolysaccharide and carbon tetrachloride, NTS-polyplex did not increase the serum levels of tumor necrosis factor alpha, interleukin (IL)-1β, IL-6, bilirubin, aspartate transaminase, and alanine transaminase. NTS-polyplex increased the levels of serum amyloid A and alkaline phosphatase, but these levels normalized after 24 h. Compared to carrageenan, the local injection of NTS-polyplex did not produce inflammation. Our results support the safety of NTS-polyplex.
dc.format.extent10
dc.identifier.citationNanomedicine. 2014 May;10(4):745-54
dc.identifier.urihttp://hdl.handle.net/11447/1020
dc.identifier.urihttp://dx.doi.org/10.1016/j.nano.2013.11.013
dc.language.isoen_US
dc.publisherFuture Medicine
dc.subjectBiosafety
dc.subjectCytotoxicity
dc.subjectNanomaterials
dc.subjectPro-inflammatory cytokines
dc.titleSafety of the intravenous administration of neurotensin-polyplex nanoparticles in BALB/c mice
dc.typeArtículo

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