Impact of antibiotic resistance on outcomes of neutropenic cancer patients with Pseudomonas aeruginosa bacteraemia (IRONIC study): study protocol of a retrospective multicentre international study

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dc.contributor.authorAlbasanz-Puig, Adaia
dc.contributor.authorGudiol, Carlota
dc.contributor.authorParody, Rocío
dc.contributor.authorTebe, Cristian
dc.contributor.authorAkova, Murat
dc.contributor.authorAraos, Rafael
dc.contributor.authorBote, Anna
dc.contributor.authorBrunel, Anne-Sophie
dc.contributor.authorCalik, Sebnem
dc.contributor.authorDrgona, Lubos
dc.contributor.authorGarcía, Estefanía
dc.contributor.authorHemmati, Philipp
dc.contributor.authorHerrera, Fabián
dc.contributor.authorIbrahim, Karim
dc.contributor.authorIsler, Burcu
dc.contributor.authorKanj, Souha
dc.contributor.authorKern, Winfried
dc.contributor.authorMaestro de la Calle, Guillermo
dc.contributor.authorManzur, Adriana
dc.contributor.authorMarin, Jorge
dc.contributor.authorMárquez-Gómez, Ignacio
dc.contributor.authorMartín-Dávila, Pilar
dc.contributor.authorMikulska, Malgorzata
dc.contributor.authorMontejo, José Miguel
dc.contributor.authorMontero, Milagros
dc.contributor.authorPaz, Hugo
dc.contributor.authorMorales, Isabel
dc.contributor.authorNovo, Andrés
dc.contributor.authorOltolini, Chiara
dc.contributor.authorPeghin, Maddalena
dc.contributor.authorDel Pozo, Jose Luis
dc.contributor.authorPuerta-Alcalde, Pedro
dc.contributor.authorRuiz-Camps, Isabel
dc.contributor.authorSipahi, Oguz
dc.contributor.authorTilley, Robert
dc.contributor.authorYáñez, Lucrecia
dc.contributor.authorRibeiro, Marisa
dc.contributor.authorCarratalà, Jordi
dc.contributor.authorIRONIC study group
dc.date.accessioned2020-09-04T17:19:13Z
dc.date.available2020-09-04T17:19:13Z
dc.date.issued2019-05
dc.descriptionInstituto de Ciencias e Innovación en Medicina (ICIM)es
dc.description.abstractIntroduction: Pseudomonas aeruginosa (PA) has historically been one of the major causes of severe sepsis and death among neutropenic cancer patients. There has been a recent increase of multidrug-resistant PA (MDRPA) isolates that may determine a worse prognosis, particularly in immunosuppressed patients. The aim of this study is to establish the impact of antibiotic resistance on the outcome of neutropenic onco-haematological patients with PA bacteraemia, and to identify the risk factors for MDRPA bacteraemia and mortality. Methods and analysis: This is a retrospective, observational, multicentre, international study. All episodes of PA bacteraemia occurring in neutropenic onco-haematological patients followed up at the participating centres from 1 January 2006 to 31 May 2018 will be retrospectively reviewed. The primary end point will be overall case-fatality rate within 30 days of onset of PA bacteraemia. The secondary end points will be to describe the following: the incidence and risk factors for multidrug-resistant and extremely drug-resistant PA bacteraemia (by comparing the episodes due to susceptible PA with those produced by MDRPA), the efficacy of ceftolozane/tazobactam, the rates of persistent bacteraemia and bacteraemia relapse and the risk factors for very early (48 hours), early (7 days) and overall (30 days) case-fatality rates. Ethics and dissemination: The Clinical Research Ethics Committee of Bellvitge University Hospital approved the protocol of the study at the primary site. To protect personal privacy, identifying information of each patient in the electronic database will be encrypted. The processing of the patients' personal data collected in the study will comply with the Spanish Data Protection Act of 1998 and with the European Directive on the privacy of data. All data collected, stored and processed will be anonymised. Results will be reported at conferences and in peer-reviewed publications.es
dc.identifier.citationAlbasanz-Puig A, Gudiol C, Parody R, et al. Impact of antibiotic resistance on outcomes of neutropenic cancer patients with Pseudomonas aeruginosa bacteraemia (IRONIC study): study protocol of a retrospective multicentre international study. BMJ Open. 2019;9(5):e025744. Published 2019 May 24. doi:10.1136/bmjopen-2018-025744es
dc.identifier.urihttp://dx.doi.org/10.1136/bmjopen-2018-025744es
dc.identifier.urihttp://hdl.handle.net/11447/3401
dc.language.isoenes
dc.publisherBMJes
dc.subjectBacteraemiaes
dc.subjectBloodstream infectiones
dc.subjectMultidrug-resistanes
dc.subjectNeutropeniaes
dc.subjectOnco-haematological patientses
dc.subjectPseudomonas aeruginosa.es
dc.titleImpact of antibiotic resistance on outcomes of neutropenic cancer patients with Pseudomonas aeruginosa bacteraemia (IRONIC study): study protocol of a retrospective multicentre international studyes
dc.typeArticlees

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