Central nystagmus and alterations in vestibular tests due to an inadvertent gentamicin administration into spinal space: A CARE case report

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dc.contributor.authorBreinbauer, Hayo
dc.contributor.authorEyzaguirre, Magdalena
dc.contributor.authorHerrero, Diego
dc.contributor.authorDelano, Paul H.
dc.date.accessioned2022-03-28T16:52:24Z
dc.date.available2022-03-28T16:52:24Z
dc.date.issued2021
dc.description.abstractIntroduction : Gentamicin has a well-known potential for damaging the peripheral vestibular organs. However, it is considered to be innocuous to the CNS as it crosses the blood-brain barrier poorly. Here, we describe central neuro-otological abnormalities developed by a patient after deployment of gentamicin into his spinal space. Case summary : A 61-year-old male unintentionally received gentamicin during spinal locoregional anesthesia for a urological procedure. During the first 48 hours the patient presented upper extremity dysmetria, dysarthria, and bilateral abducens nerve paralysis from which he recovered completely. He remained asymptomatic from day 3 to 10 after the incident. On day 11 he presented an acute vestibular syndrome. Severe bilateral vestibulopathy was confirmed by means of video head impulse testing. From day 14 onwards, he presented a persistent horizontal left-beating nystagmus, showing no variation or signs of compensation after 14 months, not responding to intensive vestibular rehabilitation or vestibular suppressant drugs. During follow-up, intercurrent gaze-evoked/direction-changing nystagmus has been recorded in various opportunities Discussion : We interpreted these findings as signs of both severe peripheral bilateral vestibulopathy and cerebellar and/or midbrain late-onset neurotoxicity, which can be explained by the intrinsic neurotoxic capability of high doses of gentamicin in the CNS.es
dc.description.versionVersión enviadaes
dc.identifier.citationBreinbauer HA, Eyzaguirre M, Herrero D, Delano PH. Central nystagmus and alterations in vestibular tests due to an inadvertent gentamicin administration into spinal space: A CARE case report. Eur Ann Otorhinolaryngol Head Neck Dis. 2021 Sep 21:S1879-7296(21)00217-9. doi: 10.1016/j.anorl.2021.07.010.es
dc.identifier.urihttps://doi.org/10.1016/j.anorl.2021.07.010es
dc.identifier.urihttp://hdl.handle.net/11447/5826
dc.language.isoenes
dc.subjectOtotoxicityes
dc.subjectNeurotoxicityes
dc.subjectGentamicines
dc.subjectCentral vertigoes
dc.subjectAdverse effectses
dc.titleCentral nystagmus and alterations in vestibular tests due to an inadvertent gentamicin administration into spinal space: A CARE case reportes
dc.typeArticlees
dcterms.sourceEuropean Annals of Otorhinolaryngology, Head and Neck Diseaseses

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