Molecular Description of a Novel Orientia Species Causing Scrub Typhus in Chile

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dc.contributor.authorAbarca, Katia
dc.contributor.authorMartínez-Valdebenito, Constanza
dc.contributor.authorAngulo, Jenniffer
dc.contributor.authorJiang, Ju
dc.contributor.authorFarris, Christina M.
dc.contributor.authorRichards, Allen L.
dc.contributor.authorAcosta-Jamett, Gerardo
dc.contributor.authorWeitzel, Thomas
dc.date.accessioned2021-07-26T21:51:25Z
dc.date.available2021-07-26T21:51:25Z
dc.date.issued2020-09
dc.description.abstractScrub typhus is a potentially fatal rickettsiosis caused by Orientia species intracellular bacteria of the genus Orientia. Although considered to be restricted to the Asia Pacific region, scrub typhus has recently been discovered in southern Chile. We analyzed Orientia gene sequences of 16S rRNA (rrs) and 47-kDa (htrA) from 18 scrub typhus patients from Chile. Sequences were ≥99.7% identical among the samples for both amplified genes. Their diversity was 3.1%–3.5% for rrs and 11.2%–11.8% for htrA compared with O. tsusugamushi and 3.0% for rrs and 14.8% for htrA compared with Candidatus Orientia chuto. Phylogenetic analyses of both genes grouped the specimens from Chile in a different clade from other Orientia species. Our results indicate that Orientia isolates from Chile constitute a novel species, which, until they are cultivated and fully characterized, we propose to designate as Candidatus Orientia chiloensis, after the Chiloé Archipelago where the pathogen was identified.es
dc.identifier.citationEmerging Infectious Diseases, 2020 august, vol.26(9), pp. 2148-2156es
dc.identifier.urihttps://doi.org/10.3201/eid2609.200918es
dc.identifier.urihttp://hdl.handle.net/11447/4198
dc.language.isoenes
dc.subjectAsiaes
dc.subjectChilees
dc.subjectHumanses
dc.subjectOrientiaes
dc.subjectOrientia tsutsugamushies
dc.subjectPhylogenyes
dc.subjectRNA, Ribosomal, 16Ses
dc.subjectScrub Typhuses
dc.titleMolecular Description of a Novel Orientia Species Causing Scrub Typhus in Chilees
dc.typeArticlees

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