Genome Sequencing Variations in the Octodon degus, an Unconventional Natural Model of Aging and Alzheimer's Disease

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dc.contributor.authorHurley, Michael
dc.contributor.authorUrra, Claudio
dc.contributor.authorGarduno, Maximiliano
dc.contributor.authorBruno, Agostino
dc.contributor.authorKimbell, Allison
dc.contributor.authorWilkinson, Brent
dc.contributor.authorMarino, Cristina
dc.contributor.authorEzquer, Marcelo
dc.contributor.authorEzquer, Fernando
dc.contributor.authorAburto, Pedro
dc.contributor.authorPoulin, Elie
dc.contributor.authorVasquez, Rodrigo
dc.contributor.authorDeacon, Robert
dc.contributor.authorAvila, Ariel
dc.contributor.authorAltimiras, Francisco
dc.contributor.authorWhitney, Peter
dc.contributor.authorZampieri, Guido
dc.contributor.authorAngione, Claudio
dc.contributor.authorConstantino, Gabriele
dc.contributor.authorHolmes, Todd
dc.contributor.authorCoba, Marcelo
dc.contributor.authorXu, Xiangmin
dc.contributor.authorCogram, Patricia
dc.date.accessioned2022-11-14T16:14:57Z
dc.date.available2022-11-14T16:14:57Z
dc.date.issued2022
dc.description.abstractThe degu (Octodon degus) is a diurnal long-lived rodent that can spontaneously develop molecular and behavioral changes that mirror those seen in human aging. With age some degu, but not all individuals, develop cognitive decline and brain pathology like that observed in Alzheimer’s disease including neuroinflammation, hyperphosphorylated tau and amyloid plaques, together with other co-morbidities associated with aging such as macular degeneration, cataracts, alterations in circadian rhythm, diabetes and atherosclerosis. Here we report the whole-genome sequencing and analysis of the degu genome, which revealed unique features and molecular adaptations consistent with aging and Alzheimer’s disease. We identified single nucleotide polymorphisms in genes associated with Alzheimer’s disease including a novel apolipoprotein E (Apoe) gene variant that correlated with an increase in amyloid plaques in brain and modified the in silico predicted degu APOE protein structure and functionality. The reported genome of an unconventional long-lived animal model of aging and Alzheimer’s disease offers the opportunity for understanding molecular pathways involved in aging and should help advance biomedical research into treatments for Alzheimer’s diseasees
dc.description.versionVersión publicadaes
dc.identifier.citationHurley MJ, Urra C, Garduno BM, Bruno A, Kimbell A, Wilkinson B, Marino-Buslje C, Ezquer M, Ezquer F, Aburto PF, Poulin E, Vasquez RA, Deacon R, Avila A, Altimiras F, Whitney-Vanderklish P, Zampieri G, Angione C, Constantino G, Holmes TC, Coba MP, Xu X and Cogram P (2022) Genome Sequencing Variations in the Octodon degus, an Unconventional Natural Model of Aging and Alzheimer’s Disease. Front. Aging Neurosci. 14:894994. doi:10.3389/fnagi.2022.894994es
dc.identifier.urihttps://doi.org/ doi:10.3389/fnagi.2022.894994es
dc.identifier.urihttp://hdl.handle.net/11447/6654
dc.language.isoenes
dc.subjectAlzheimer’s diseasees
dc.subjectAginges
dc.subjectGenomees
dc.subjectAPOEes
dc.subjectAmyloidses
dc.subjectLipid dropletses
dc.subjectOctodon deguses
dc.subjectDrug developmentes
dc.titleGenome Sequencing Variations in the Octodon degus, an Unconventional Natural Model of Aging and Alzheimer's Diseasees
dc.typeArticlees
dcterms.sourceFrontiers in Aging Neurosciencees

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