Prognostic Significance of Hyperglycemia in Acute Intracerebral Hemorrhage: The INTERACT2 Study.

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dc.contributor.authorSaxena, Anubhav
dc.contributor.authorAnderson, Craig
dc.contributor.authorWang, Xia
dc.contributor.authorSato, Shoichiro
dc.contributor.authorArima, Hisatomi
dc.contributor.authorChan, Edward
dc.contributor.authorMuñoz, Paula
dc.contributor.authorDelcourt, Candice
dc.contributor.authorThompson, Robinson
dc.contributor.authorStapf, Christian
dc.contributor.authorLavados, Pablo
dc.contributor.authorWang, Jiguang
dc.contributor.authorBruce, Neal
dc.contributor.authorChalmers, John
dc.contributor.authorHeeley, Emma
dc.contributor.authorINTERACT2 Investigators
dc.date.accessioned2017-01-06T13:06:43Z
dc.date.available2017-01-06T13:06:43Z
dc.date.issued2016
dc.description.abstractBACKGROUND AND PURPOSE: We aimed to determine associations of baseline blood glucose and diabetes mellitus with clinical outcomes in participants of the Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT2). METHODS: INTERACT2 was an international prospective, open, blinded end point, randomized controlled trial of 2839 patients with spontaneous intracerebral hemorrhage (<6 hours) and elevated systolic blood pressure randomly assigned to intensive (target systolic blood pressure <140 mm Hg) or guideline-based (systolic blood pressure <180 mm Hg) BP management. Associations of hyperglycemia at presentation (>6.5 mmol/L) and combined and separate poor outcomes of death and major disability (scores of 3-6, 3-5, and 6, respectively, on the modified Rankin scale) at 90 days were determined in logistic regression models. RESULTS: In 2653 patients with available data, there were 1348 (61%) with hyperglycemia and 292 (11%) with diabetes mellitus. Associations of baseline blood glucose and poor outcome were strong and near continuous. After adjustment for baseline variables, the highest fourth (7.9-25.0 mmol/L) of blood glucose was significantly associated with combined poor outcome (adjusted odds ratio 1.35, 95% confidence interval 1.01-1.80; P trend 0.015). Diabetes mellitus also predicted poor outcome (adjusted odds ratio 1.46, 95% confidence interval 1.05-2.02; P=0.023), though more important for residual disability than death on separate analysis. CONCLUSIONS: Hyperglycemia and diabetes mellitus are independent predictors of poor outcome in patients with predominantly mild to moderate severity of intracerebral hemorrhage. These data support guideline recommendations for good glycemic control in patients with intracerebral hemorrhage.
dc.identifier.citationSaxena A, Anderson CS, Wang X, Sato S, Arima H, Chan E, Muñoz-Venturelli P, Delcourt C, Robinson T, Stapf C, Lavados PM, Wang J, Neal B, Chalmers J, Heeley E; INTERACT2 Investigators. Prognostic Significance of Hyperglycemia in Acute Intracerebral Hemorrhage: The INTERACT2 Study. Stroke. 2016 Mar;47(3):682-8
dc.identifier.urihttp://hdl.handle.net/11447/935
dc.identifier.urihttp://dx.doi.org/ 10.1161/STROKEAHA.115.011627
dc.language.isoen_US
dc.publisherAmerican Heart Association, Inc.
dc.subjectClinical trial
dc.subjectDeath
dc.subjectDiabetes mellitus
dc.subjectDisability
dc.subjectHyperglycemia
dc.subjectOutcome
dc.subjectPrognosis
dc.titlePrognostic Significance of Hyperglycemia in Acute Intracerebral Hemorrhage: The INTERACT2 Study.
dc.typeArtículo

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