Estimated impact of maternal vaccination on global paediatric influenzarelated in-hospital mortality: A retrospective case series

dc.contributor.authorLowensteyn, Yvette N.
dc.contributor.authorNairb, Harish
dc.contributor.authorNunes, Marta C.
dc.contributor.authorRoessel, Ichelle van
dc.contributor.authorVernooij, Femke S.
dc.contributor.authorWillemsen, Joukje
dc.contributor.authorMazur, Natalie I.
dc.contributor.authorBont, Louis J.
dc.contributor.authorFLU GOLD study group
dc.contributor.authorDíaz, Franco
dc.date.accessioned2021-12-09T16:41:20Z
dc.date.available2021-12-09T16:41:20Z
dc.date.issued2021
dc.description.abstractBackground Influenza virus infection is an important cause of under-five mortality. Maternal vaccination protects children younger than 3 months of age from influenza infection. However, it is unknown to what extent paediatric influenza-related mortality may be prevented by a maternal vaccine since global age-stratified mortality data are lacking. Methods We invited clinicians and researchers to share clinical and demographic characteristics from children younger than 5 years who died with laboratory-confirmed influenza infection between January 1, 1995 and March 31, 2020. We evaluated the potential impact of maternal vaccination by estimating the number of children younger than 3 months with in-hospital influenza-related death using published global mortality estimates. Findings We included 314 children from 31 countries. Comorbidities were present in 166 (53%) children and 41 (13%) children were born prematurely. Median age at death was 8·6 (IQR 4·5–16·6), 11·5 (IQR 4·3–24·0), and 15·5 (IQR 7·4–27·0) months for children from low- and lower-middle-income countries (LMICs), upper-middle-income countries (UMICs), and high-income countries (HICs), respectively. The proportion of children younger than 3 months at time of death was 17% in LMICs, 12% in UMICs, and 7% in HICs. We estimated that 3339 annual influenza-related in-hospital deaths occur in the first 3 months of life globally. Interpretation In our study, less than 20% of children is younger than 3 months at time of influenza-related death. Although maternal influenza vaccination may impact maternal and infant influenza disease burden, additional immunisation strategies are needed to prevent global influenza-related childhood mortality. The missing data, global coverage, and data quality in this study should be taken into consideration for further interpretation of the results.es
dc.identifier.citationYvette N Löwensteyn, Harish Nair, Marta C Nunes, Ichelle van Roessel, Femke S Vernooij, Joukje Willemsen, Louis J Bont, Natalie I Mazur. Estimated impact of maternal vaccination on global paediatric influenza-related in-hospital mortality: A retrospective case series. In: EClinicalMedicine, Volume 37, 2021, 100945, https://doi.org/10.1016/j.eclinm.2021.100945.es
dc.identifier.urihttps://doi.org/10.1016/j.eclinm.2021.100945.es
dc.identifier.urihttp://hdl.handle.net/11447/5210
dc.language.isoenes
dc.subjectMaternal vaccinationes
dc.subjectImpactes
dc.subjectPaediatric influenzaes
dc.titleEstimated impact of maternal vaccination on global paediatric influenzarelated in-hospital mortality: A retrospective case serieses
dc.typeArticlees
dcterms.sourceEClinicalMedicinees

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