Initial-onset acute and chronic recurrent stages are two distinctive courses of VogtKoyanagi-Harada disease

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dc.contributor.authorUrzĂșa, Cristhian
dc.contributor.authorHerbort Jr., Carl
dc.contributor.authorValenzuela, Rodrigo A.
dc.contributor.authorEl-Asrar, Ahmed M. Abu
dc.contributor.authorArellanes-Garcia, Lourdes
dc.contributor.authorSchlaen, Ariel
dc.contributor.authorYamamoto, Joyce
dc.contributor.authorPavesio, Carlos
dc.date.accessioned2021-08-20T13:45:37Z
dc.date.available2021-08-20T13:45:37Z
dc.date.issued2020
dc.description.abstractPurpose: To describe distinctive stages of Vogt-Koyanagi-Harada (VKH) disease: initial-onset acute versus chronic recurrent disease. Methods: A comprehensive literature review regarding stages and clinical presentations of VKH disease was conducted. Results: Despite a list of signs that has been described as characteristic features of early or late phases of VKH disease, the current classification -developed by an international committee and published in 2001- does not consider a distinction regarding the time from onset of disease symptoms, and specific findings observed at certain time point from the symptoms presentation and outcomes related to the stage of VKH disease. In that sense, chronic recurrent VKH disease is more refractory to treatment and is associated with a higher rate of complications. Accordingly, this subset of VKH patients has poorer functional and anatomical outcomes than patients with an initial-onset acute disease. Conclusions: An early clear distinction of VKH phenotype [Initial-onset acute versus chronic recurrent disease] should be considered in each clinical scenario, evaluating the delay in diagnosis and the clinical presentation, since it may help clinicians to perform a correct disease prognosis categorization and thus to make treatment decisions in terms of potential refractoriness or expected clinical outcomes.es
dc.identifier.citationJournal of Ophthalmic Inflammation and Infection, 2020, vol.10:23es
dc.identifier.urihttps://doi.org/10.1186/s12348-020-00214-2es
dc.identifier.urihttp://hdl.handle.net/11447/4381
dc.language.isoenes
dc.subjectVogt-Koyanagi-Harada diseasees
dc.subjectInitial-onset acute VKHes
dc.subjectChronic VKHes
dc.subjectCategorizationes
dc.titleInitial-onset acute and chronic recurrent stages are two distinctive courses of VogtKoyanagi-Harada diseasees
dc.typeArticlees

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