Role of Astroglial Hemichannels and Pannexons in Memory and Neurodegenerative Diseases
Date
2016
Type:
Artículo
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Publisher
Lausanne, Switzerland : Frontiers Research Foundation
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Abstract
Under physiological conditions, astroglial hemichannels and pannexons allow the release of gliotransmitters from astrocytes. These gliotransmitters are critical in modulating synaptic transmission, plasticity and memory. However, recent evidence suggests that under pathological conditions, they may be central in the development of various neurodegenerative diseases. Here we review current literature on the role of astroglial hemichannels and pannexons in memory, stress and the development of neurodegenerative diseases, and propose that they are not only crucial for normal brain function, including memory, but also a potential target for the treatment of neurodegenerative diseases.
Description
Centro de Fisiología Celular e Integrativa
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Citation
Frontiers in Integrative Neuroscience
Keywords
Cx hemichannels, Connexin 43, Astrocytes, Connexin hemichannels, Memory, Pannexin